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https://onlinelibrary.wiley.com/doi/book/10.1002/9781118444726
Jan 21, 2013 · Drug Delivery Strategies for Poorly Water-Soluble Drugs is an essential multidisciplinary guide to this important area of drug formulation for researchers in industry and academia working in drug delivery, polymers and biomaterials.
https://www.tandfonline.com/doi/full/10.1517/17425247.4.4.403
May 12, 2005 · For the poorly water-soluble drugs with poor membrane permeability, which belong to BCS class IV, formulation strategies can do little to improve their absorption due to the limited membrane permeability; the best solution to improve their bioavailability is to go back to the lead optimisation phase of drug discovery and modify their structures to obtain the appropriate physicochemical properties …Author: Alfred Fahr, Xiangli Liu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629443/
Aug 24, 2015 · About 40% of drugs with market approval and nearly 90% of molecules in the discovery pipeline are poorly water-soluble. With the advent of various insoluble drug delivery technologies, the challenge to formulate poorly water soluble drugs could be achieved.Author: Sandeep Kalepu, Vijaykumar Nekkanti
https://www.researchgate.net/publication/277705442_Drug_Delivery_Strategies_for_Poorly_Water-Soluble_Drugs
Nanoparticles are a drug delivery platform that can enhance the efficacy of active pharmaceutical ingredients, including poorly-water soluble compounds, ionic drugs, proteins, peptides, siRNA and ...
https://www.researchgate.net/publication/6156786_Drug_delivery_strategies_for_poorly_water-soluble_drugs
This challenges drug delivery institutions in industry or academia to develop carrier systems for the optimal oral and parenteral administration of these drugs. To mention only a few of the challenges for this class of drugs: their oral bioavailability is poor and highly variable,...
https://www.researchgate.net/publication/277693709_Drug_Delivery_Strategies_for_Poorly_Water-Soluble_Drugs
Antisolvent precipitation is a widely used technique for the manufacture of nanosuspensions of poorly water-soluble drugs. Several approaches such as statix mixers, ultrasonication, microfluidic reactors, spray-–freezing into liquid and supercritical fluids have been employed to engineer nanosuspensions.Author: Dennis Douroumis
https://www.sciencedirect.com/science/article/pii/S0378517311007940
Particle size reduction to nano-meter range (<1 μm) is an attractive approach for poorly water-soluble drugs. As described in Section 3.2.1, particle size reduction could lead to an increase of the surface area and a decrease of the diffusion layer thickness, which …Author: Yohei Kawabata, Yohei Kawabata, Koichi Wada, Manabu Nakatani, Shizuo Yamada, Satomi Onoue
https://www.sciencedirect.com/science/article/pii/S2211383515001069
Majority of the failures in new drug development have been attributed to poor water solubility of the drug. Issues associated with poor solubility can lead to low bioavailability resulting in suboptimal drug delivery. About 40% of drugs with market approval and nearly 90% of molecules in the discovery pipeline are poorly water-soluble.Author: Sandeep Kalepu, Vijaykumar Nekkanti
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