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https://www.sciencedirect.com/topics/chemistry/micellar-drug
Among representative studies on polymeric drug carriers responding to physical or biological signals for effective cytosolic drug delivery is the acidic pH-activating system folate–PEG-poly(aspartate hydrazone doxorubicin) [folate-PEG-(PAsp-Hyd-DOX)] (Figure 13.47), in which a multifunctionalized block copolymer contains a folate ligand and a hydrazone bond between the drug and the polymer.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047275/
Feb 26, 2020 · 2. Size Impact on Delivery Efficacy. As one of the most important characteristics of nanoparticles, size greatly influences the efficiency of tumor targeted drug delivery in many ways, including circulation, biodistribution, tumor accumulation and penetration, as well as cellular uptake and subcellular distribution.
https://www.tandfonline.com/doi/pdf/10.1080/15548627.2016.1256523
during the 1st swelling-shrinking cycle, but could last for 5 cycles under our evaluation condition (Fig. S5). In vitro intercellular drug delivery ability of D/PSP@M/GNP In contrast to D/PP, the intracellular yellow large-area fluores-cence indicated the successful expansion of D/PSP within Figure 1.
https://www.nature.com/articles/s41598-017-13320-4
Oct 16, 2017 · Dual-Drug Containing Core-Shell Nanoparticles for Lung Cancer Therapy ... which would cause shrinking of the ... This nanoparticle platform utilizes …Author: Jyothi U. Menon, Jyothi U. Menon, Aneetta Kuriakose, Aneetta Kuriakose, Roshni Iyer, Roshni Iyer, El...
https://zcgroup.cpu.edu.cn/_upload/article/files/96/e0/b5f4ca48411c9b780eb612287f2a/668de1fc-69d6-4812-9ace-aec06b53d22b.pdf
shrinking nanogel in response to pH variation for a sequential intra-intercellular NP delivery. The nanogel had a crosslinked polyelectrolyte core, consisting of N-lysinal-N’-succinyl chito-san and poly(N-isopropylacrylamide), and a crosslinked bovine serum albumin shell, which was able to swell in an
https://www.researchgate.net/publication/232257568_Drug_delivery_systems_An_updated_review
Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. For the treatment of human diseases, nasal and pulmonary ...
http://core.ac.uk/display/16410876
The resulting biomaterial was incorporated into a nanoparticle drug delivery system. By combining gold nanoparticles with highly branched pNIPAAm, which was designed to entrap small molecule drugs, a hybrid system was synthesized where heating of the nanoparticle through surface plasmon resonance can trigger drug release from the pNIPAAm.Author: Kai Chang
https://www.tandfonline.com/doi/abs/10.1080/15548627.2016.1256523
Apr 28, 2016 · To further enhance the intensity of deep tumor drug delivery and integrate a combined therapy, we herein report on a core-shell nanocarrier that could simultaneously overcome the double barriers of the extracellular matrix (ECM) and multiple layers of tumor cells (MLTC).Author: Yang Wang, Yue Qiu, Sheng Yin, Li Zhang, Kairong Shi, Huile Gao, Zhirong Zhang, Qin He
https://www.hindawi.com/journals/jnm/2017/6796412/
Temperature- and pH-responsive core/shell nanoparticles were prepared by semicontinuous heterophase polymerization of N-isopropylacrylamide (NIPA) in the presence of chitosan micelles for drug delivery purposes. Micelles of chitosan, formed in an acetic acid aqueous solution at 70°C containing potassium persulfate, were fed with N-isopropylacrylamide (NIPA) at a controlled rate, to produce ...Author: Abraham G. Alvarado, Andres Ortega, Lourdes A. Pérez-Carrillo, Israel Ceja, Martin Arellano, R. Guil...
https://www.researchgate.net/publication/336682946_Polymeric_microneedles_for_controlled_transdermal_drug_delivery
Polymeric microneedle (MN) systems are interesting transdermal drug delivery systems because of their controlled drug delivery, tunable properties, and ease of patient self-administration.
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