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https://www.sciencedirect.com/science/article/pii/S1359644616000209
A cubosomal drug delivery system containing a hydrophilic anticancer drug, 5-fluorouracil (5-FU), for liver targeting, indicated that the 5-FU-loaded cubosome significantly increased 5-FU liver concentration, a value approximately fivefold greater than that observed with a 5-FU solution . In summary, several characteristics have made cubosomes an ideal drug delivery carrier:Author: Zahra Karami, Mehrdad Hamidi
https://www.onlinelibrary.wiley.com/doi/full/10.1002/anie.201804067
Jun 21, 2018 · A key application for cubosome systems is the delivery of drugs and proteins to treat disease. Lipid systems have already widely been used for delivery applications, although commonly these are loaded vesicles. A key difference between vesicles and cubosomes is the internal aqueous volume and the membrane surface area.Author: Hanna M. G. Barriga, Margaret N. Holme, Molly M. Stevens, Molly M. Stevens
https://gsconlinepress.com/journals/gscbps/sites/default/files/GSCBPS-2018-0089.pdf
Drug delivery vehicle is a common application for such new materials. The research in association with cosmetic companies like L’Oreal and Nivea are trying for the use of cubosome particles as oil-in-water emulsion stabilizers and pollutant absorbents in cosmetics [16].Author: Sadhu Venkateswara Rao, Beram Naga Sravya, Kantamneni Padmalatha
https://www.sciencedirect.com/science/article/pii/S1567539420300232
Cubosome nanocarriers are promising biomimetic drug delivery systems used in particular for highly toxic drugs in cases where decreasing unwanted side effects is especially important.
http://ijpsr.com/bft-article/cubic-liquid-crystalline-nanoparticles-cubosomes-a-novel-carrier-for-drug-delivery/?view=fulltext
Cubosomes for Ophthalmic Drug Delivery: Drugs were administered to the eyes as drops in general because of the blinking, tears, nasolacrimal drainage drug removal is often. pH, the lipophilicity of the drug and corneal epithelium were the considerable facts that affect poor bioavailability of the drugs.
https://www.researchgate.net/publication/328649787_A_review_on_cubosome_The_novel_drug_delivery_system
Cubosomes are nanostructured liquid crystalline particles, made of certain amphiphilic lipids in definite proportions, known as biocompatible carriers in drug delivery.
https://www.nature.com/articles/s41467-019-12508-8
Oct 03, 2019 · Drug delivery with nanocarriers relies on the interaction of individual nanocarriers with the cell surface.Author: Brendan P. Dyett, Haitao Yu, Jamie Strachan, Calum J. Drummond, Charlotte E. Conn
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974159/
Aug 06, 2010 · One promising strategy to overcome these limitations is to encapsulate this drug using nanocarriers or nanoparticulate systems intended for controlled drug delivery. Fig. 1 Selected physicochemical properties of key ingredients used in the cubosome nanoformulation: a Dacarbazine, (DTIC, C 6 H 10 N 6 O, pka: 4.42, MW: 182.18, mp: ~205°C, water solubility: 4220 mg/L, logP = −1.6; …Author: Di Bei, Tao Zhang, James B. Murowchick, Bi-Botti C. Youan
https://www.hindawi.com/journals/ap/2014/574673/
Vesicular drug delivery system sustains drug action at a predetermined rate, relatively constant (zero order kinetics), efficient drug level in the body, and simultaneously minimizes the undesirable side effects. It can also localize drug action in the diseased tissue or organ by targeted drug delivery using carriers or chemical derivatization.Author: Shikha Jain, Vikas Jain, S. C. Mahajan
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