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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839363/
Feb 01, 2010 · Treatment of diseases of the posterior segment of the eye, such as age-related macular degeneration, cytomegalovirus retinitis, diabetic retinopathy, posterior uveitis and retinitis pigmentosa, requires novel drug delivery systems that can overcome the many barriers for efficacious delivery of therapeutic drug concentrations.Author: Shalin S Shah, Lori Vidal Denham, Jasmine R Elison, Partha S Bhattacharjee, Christian Clement, Tashf...
https://www.ondrugdelivery.com/sustained-drug-delivery-posterior-segments-eye/
When administered topically, drug concentrations in the retina and choroid are many-fold lower than the tear fluid. Drug delivery to the posterior segment of the eye is most efficiently achieved by local, ocular routes of administration, which includes intravitreal, subretinal, suprachoroidal and …
https://www.sciencedirect.com/science/article/pii/S1359644610008421
Drug delivery to the posterior segment of the eye is therefore compounded by the increasing number of new therapeutic entities (e.g. oligonucleotides, aptamers and antibodies) and the need for chronic therapy. Currently, the intravitreal route is widely used to deliver therapeutic entities to the retina.Author: Thilini Rasika Thrimawithana, Simon Young, Craig Robert Bunt, Colin Green, Raid Ghassan Alany
https://www.researchgate.net/publication/47810056_Drug_delivery_to_the_posterior_segment_of_the_eye
Abstract. Drug delivery into the posterior segment of the eye is complicated by the presence of the blood-ocular barrier. Strategies for delivering drugs to the posterior segment include systemic ...
https://www.researchgate.net/publication/12563316_Drug_delivery_for_posterior_segment_eye_disease_Invest_Ophthalmol_Vis_Sci
Intravitreal administration is the method of choice for drug delivery to the posterior segment of the eye with special emphasis on the vitreous body and its surrounding retinal vasculature.
https://link.springer.com/book/10.1007%2F978-3-319-95807-1
Thus, this timely reference Drug Delivery for the Retina and Posterior Segment Disease compiles and analyzes recent advances in the research and development of drug delivery systems for retina and posterior segment diseases of the eye, with an emphasis on the use of implantable devices, iontophoresis as well as micro- and nanoparticles.
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