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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844929/
RBC is naturally designed as a biocompatible carrier for vascular drug delivery, with prolonged life-time in circulation and safe mechanisms for eventual elimination including fixation of complement and uptake by macrophages. Drug encapsulation into RBC and coupling to RBC surface represent two approaches for RBC drug delivery. 2.
https://www.tandfonline.com/doi/abs/10.1517/17425241003610633
Dec 19, 2012 · Drug delivery by red blood cells: vascular carriers designed by mother nature. Importance of the field: Vascular delivery of several classes of therapeutic agents may benefit from carriage by red blood cells (RBC), for example, drugs that require delivery into phagocytic cells and those that must act within the vascular lumen.Author: Vladimir R. Muzykantov
https://www.researchgate.net/publication/41655035_Drug_delivery_by_red_blood_cells_vascular_carriers_designed_by_Mother_Nature
Drug delivery by red blood cells: vascular carriers designed by Mother Nature Article · Literature Review (PDF Available) in Expert Opinion on Drug Delivery 7(4):403-27 · March 2010 with 383 ReadsAuthor: Vladimir Muzykantov
http://europepmc.org/articles/PMC2844929
Apr 01, 2010 · RBC is naturally designed as a biocompatible carrier for vascular drug delivery, with prolonged life-time in circulation and safe mechanisms for eventual elimination including fixation of complement and uptake by macrophages. Drug encapsulation into RBC and coupling to RBC surface represent two approaches for RBC drug delivery.
https://iubmb.onlinelibrary.wiley.com/doi/full/10.1002/iub.478
Jul 15, 2011 · It is very difficult to envisage a vascular drug delivery system better suited for the scope than the red blood cell. These “carriers” naturally circulate for 120 days and are removed from circulation not randomly but by selected recognition mechanisms.Author: Sara Biagiotti, Maria Filomena Paoletti, Alessandra Fraternale, Luigia Rossi, Mauro Magnani
http://onlinelibrary.wiley.com/doi/10.1002/iub.478/full
Jul 21, 2011 · Loading of drug‐binding proteins for the delivery of diffusible drugs. A recombinant protein, able to selectively bind a selected drug, is entrapped into red blood cells. The protein‐loaded red blood cells can reversibly bind the drug added ex‐vivo (i.e.,...
https://www.nature.com/articles/s41467-018-04791-8
Jun 15, 2018 · Here we sought to harness eukaryotes’ natural mechanism for RNA exchange and intercellular communication, the extracellular vesicles (EVs), to employ them as RNA drug delivery vehicles. The natural delivery of microRNAs and mRNAs by EVs was first discovered in mast cells by Valadi et al..Author: Waqas Muhammad Usman, Tin Chanh Pham, Yuk Yan Kwok, Luyen Tien Vu, Victor Ma, Boya Peng, Yuen San Ch...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424548/
Nov 15, 2016 · Red blood cells (RBCs) constitute a unique drug delivery system as a biologic or hybrid carrier capable of greatly enhancing pharmacokinetics, altering pharmacodynamics (for example, by changing margination within the intravascular space), and modulating immune responses to …Author: Carlos H. Villa, Aaron C. Anselmo, Samir Mitragotri, Vladimir Muzykantov
https://www.pnas.org/content/111/28/10131
Jul 15, 2014 · Engineered red blood cells as carriers for systemic delivery of a wide array of functional probes Jiahai Shi , Lenka Kundrat , Novalia Pishesha , Angelina Bilate , Chris Theile , Takeshi Maruyama , Stephanie K. Dougan , Hidde L. Ploegh , and Harvey F. LodishAuthor: Jiahai Shi, Lenka Kundrat, Novalia Pishesha, Angelina Bilate, Chris Theile, Takeshi Maruyama, Stepha...
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