We have collected information about Drug Delivery And Transport Of Solid Tumors for you. Follow the links to find out details on Drug Delivery And Transport Of Solid Tumors.
https://link.springer.com/article/10.1023%2FA%3A1025785505977
Sep 01, 2003 · Drug delivery to solid tumors consists of multiple processes, including transport via blood vessels, transvascular transport, and transport through interstitial spaces. These processes are dynamic and change with time and tumor properties and are affected by multiple physicochemical factors of a drug, multiple tumor biologic factors,...Author: Seong Hoon Jang, M. Guillaume Wientjes, Dan Lu, Jessie L.-S. Au
https://www.sciencedirect.com/science/article/pii/S016836590100308X
Jul 06, 2001 · Because drug-induced apoptosis is a dynamic process, the delivery of these drugs to cells in a solid tumor is also a dynamic process, determined by both the drug concentration and the treatment duration in addition to the usual processes involved in drug transport (i.e. distribution through vascular space, transport across microvessel walls ...Author: J.L.-S. Au, S.H. Jang, J. Zheng, C.-T. Chen, S. Song, L. Hu, M.G. Wientjes
https://www.sciencedirect.com/science/article/abs/pii/S016836590100308X
The transport of highly protein-bound drugs such as paclitaxel and doxorubicin in a solid tumor is retarded by a high tumor cell density and enhanced by drug-induced apoptosis. Accordingly, the delivery of a highly protein-bound drug to cells in a solid tumor is affected by its apoptotic effects and is therefore determined by the drug ...Author: J.L.-S. Au, S.H. Jang, J. Zheng, C.-T. Chen, S. Song, L. Hu, M.G. Wientjes
https://jbioleng.biomedcentral.com/articles/10.1186/1754-1611-6-4
Dec 01, 2012 · In studying tumor modeling, the numerical method, which introduces more features of drug delivery to solid tumors, is more effective than the analytical method. To design an optimum scheme for drug delivery, the transport mechanisms and obstacles to drug delivery have to be clarified, which is one of the main objectives of this paper.Author: M Soltani, Pu Chen
https://www.dovepress.com/drug-delivery-to-solid-tumors-the--predictive-value-of-the-multicellul-peer-reviewed-article-IJN
Drug delivery to solid tumors: the predictive value of the multicellular tumor spheroid model for nanomedicine screening Marie Millard,1,2 Ilya Yakavets,1–3 Vladimir Zorin,3,4 Aigul Kulmukhamedova,1,2,5 Sophie Marchal,1,2 Lina Bezdetnaya1,2 1Centre de Recherche en Automatique de Nancy, Centre National de la Recherche Scientifique UMR 7039, Université de Lorraine, …Author: Marie Millard, Ilya Yakavets, Vladimir Zorin, Aigul Kulmukhamedova, Sophie Marchal, Lina Bezdetnaya
https://link.springer.com/article/10.1007/BF02456636
Dec 01, 1998 · The effect of tumor microvasculature, lymph function, drug injection mode, the molecular weight and binding kinetics of the drug on the distribution in tumors are also considered. Based on the flow field solution of the three-porous-medium model for tumor microcirculation, the diffusion-convection equations are solved with various inAuthor: Lei Xiaoxiao, Wu Wangyi, Wen Gongbi, Chen Jianguo
https://www.sciencedirect.com/science/article/pii/S1053429698800428
Transvascular Drug Delivery in Solid Tumors f arz Yua12 The microvessel wall is a barrier for the delivery of various therapeutic agents to tumor cells. Tumor mi- crovessels are, in general, more permeable to macromol- ecules than normal vessels.Author: Fan Yuan
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106925/
Jul 22, 2014 · The complexity of the in vivo system thus inflicts multiple biological barriers which impedes NP drug delivery to solid tumors. 2 In current anti-cancer therapies, NPs are generally administered intravenously (IV). This route is fast, reliable and allows complete distribution via the systemic circulation.Author: Shravan Kumar Sriraman, Bhawani Aryasomayajula, Vladimir P Torchilin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076317/
Solving fluid flow and solute transport equations simultaneously, the effects of tumor shape, size, and tissue transport properties on drug delivery to solid tumor are also investigated. Spherical and non-spherical tumors and their surrounding normal tissue are …Author: Mostafa Sefidgar, M Soltani, Kaamran Raahemifar, Hossein Bazmara, Seyed Mojtaba Mousavi Nayinian, Ma...
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