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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700785/
Today, there are 19 transdermal delivery systems for such drugs as estradiol, fentanyl, lidocaine and testosterone; combination patches containing more than one drug for contraception and hormone replacement; and iontophoretic and ultrasonic delivery systems for analgesia (Table 1, Fig. 1). Between 1979 and 2002, a new patch was approved on average every 2.2 years.Author: Mark R Prausnitz, Robert Langer
https://deepblue.lib.umich.edu/bitstream/handle/2027.42/50213/430130209_ftp.pdf?sequence=1
respect to the delivery method, this report actually places transdermal delivery in a positive light, for, when the principles set forth are applied, one can rule out unworthy drugs and concentrate effort on candidates of high promise.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852070/
For most drug compounds, total body clearance is the product of volume of distribution and total elimination rate (K E ), CL T = K E × V d ….2. Thus the required flux from a transdermal patch can be calculated by normalizing the dosing rate Eqn. 1 for the surface …
https://www.jrnlappliedresearch.com/articles/Vol2Iss1/Hull.htm
In order for a drug to be a practical candidate for transdermal delivery, it must possess physicochemical properties that are associated with relatively high permeability. These properties include a low-molecular-weight (<1000) and adequate solubility in oil and water.
http://ijpsr.com/bft-article/transdermal-drug-delivery-system-a-review/?view=fulltext
7 Disadvantages of transdermal drug delivery: 8, 17, 19. Transdermal drug delivery system cannot deliver ionic drugs. It cannot achieve high drug levels in blood. It cannot develop for drugs of large molecular size. It cannot deliver drugs in a pulsatile fashion. It cannot develop if drug or formulation causes irritation to skin.
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/transdermal-delivery
Transdermal delivery of drug formulations (Panchagnula et al., 1997) has proven to be an effective method in some monkey species (Rupniak et al., 1989a, 1989b; Spilman et al., 1984; Smith et al., 2000). Substances can be applied in paste or solution form directly to …
https://ijpsr.com/bft-article/approaches-and-significance-of-transdermal-drug-delivery-systems-a-review/?view=fulltext
A Transdermal Drug Delivery Systems (TDDS) or transdermal patch is defined as a flexible, multilaminated, pharmaceutical preparation of varying size containing one or more drug substances to be applied to the intact skin for systemic circulation to maintain the plasma level.
https://www.slideshare.net/sagarsavale1/drug-selection-criteria-for-different-drug-delivery-system
Aug 13, 2016 · 13-Aug-168 COLON TARGETED DRUG DELIVERY Drug Selection Criteria Drugs which show poor absorption from stomach or intestine are the best candidates. Peptides, proteins, oligonucleotides and vaccines are potential candidates for colon targeted DDS. Drugs used in the treatment of inflammatory bowel disease, ulcerative colitis, diarrhoea and colon cancer are ideal …
https://www.slideshare.net/optimpharma/transdermal-drug-delivery-system-11813407
Mar 01, 2012 · Transdermal Drug Delivery System 1. Transdermal drug delivery system 2. Introduction1,2 -The use of the transdermal route has been well established since the1800s.There is considerable interest in the skin as a site of drug application bothfor local and systemic effects.Transdermal drug delivery systems allow delivery of a drug into thesystemic ci
https://www.sciencedirect.com/science/article/pii/S0169409X17301801
Transdermal drug delivery is a prospective drug delivery strategy to complement the limitations of conventional drug delivery systems including oral and injectable methods. This delivery route allows both convenient and painless drug delivery and a sustained release profile with reduced side effects.Author: Hyunjae Lee, Changyeong Song, Seungmin Baik, Dokyoon Kim, Taeghwan Hyeon, Dae-Hyeong Kim
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