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https://www.researchgate.net/publication/6355634_Drug_and_Gene_Delivery_by_Bubble_Liposomes_and_Ultrasound
In vitro gene delivery, Bubble liposomes could deliver plasmid DNA to many cell types such as tumor cells, T cell line and endothelial cells without cytotoxicity.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095404/
3.2. Gene Transfection with Bubble Liposomes and Ultrasound Exposure into Joint Synovium In Vivo. A local gene delivery system to the joint synovium by BL and US exposure may be easily applied, because the injected BL may be retained in the confined joint space and percutaneous US exposure may induce cavitations on the surface of the synovium.Author: Yoichi Negishi, Yuka Tsunoda, Yoko Endo-Takahashi, Yusuke Oda, Ryo Suzuki, Kazuo Maruyama, Matsuo Ya...
https://www.researchgate.net/publication/230005886_Drug_and_Gene_Delivery_by_Bubble_Liposomes_and_Ultrasound
Ultrasound-triggered gene and drug delivery systems are widely investigated [13]; they are usually designed as ultrasound-sensitive micro-and nanoparticles, that respond to insonation by selective ...
https://onlinelibrary.wiley.com/doi/10.1111/jre.12119
Jul 24, 2013 · Relative luciferase activity, 1 d after gene delivery, was significantly higher in gingiva treated using Bubble liposomes and ultrasound than in gingiva of the other treatment groups. Histological analysis also showed that distinct EGFP‐expressing cells were observed in transfected gingiva when rats were treated under optimized conditions.Author: M. Sugano, M. Sugano, Y. Negishi, Y. Endo-Takahashi, N. Hamano, M. Usui, R. Suzuki, K. Maruyama, Y. ...
https://www.hindawi.com/journals/jdd/2011/203986/
Gene Transfection with Bubble Liposomes and Ultrasound Exposure into Joint Synovium In Vivo A local gene delivery system to the joint synovium by BL and US exposure may be easily applied, because the injected BL may be retained in the confined joint space and percutaneous US exposure may induce cavitations on the surface of the synovium.Author: Yoichi Negishi, Yuka Tsunoda, Yoko Endo-Takahashi, Yusuke Oda, Ryo Suzuki, Kazuo Maruyama, Matsuo Ya...
https://www.ncbi.nlm.nih.gov/pubmed/21603202
Local gene delivery system by bubble liposomes and ultrasound exposure into joint synovium. Negishi Y(1), Tsunoda Y, Endo-Takahashi Y, Oda Y, Suzuki R, Maruyama K, Yamamoto M, Aramaki Y. Author information: (1)Department of Drug and Gene Delivery Systems, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi ...Author: Yoichi Negishi, Yuka Tsunoda, Yoko Endo-Takahashi, Yusuke Oda, Ryo Suzuki, Kazuo Maruyama, Matsuo Ya...
https://www.ncbi.nlm.nih.gov/pubmed/23889504
The physical action of an ultrasound may be able to deliver a therapeutic gene or drugs into the local area of the periodontium being treated for periodontal regeneration. Previously, we developed "Bubble liposomes" as a useful carrier for gene or drug delivery, and reported that delivery efficiency was increased with high-frequency ultrasound in vitro and in vivo.Author: M. Sugano, M. Sugano, Y. Negishi, Y. Endo-Takahashi, N. Hamano, M. Usui, R. Suzuki, K. Maruyama, Y. ...
https://www.sciencedirect.com/science/article/pii/B9780124077225000165
This characteristic has been used for site-directed drug and gene delivery of chemotherapy using high-intensity focused ultrasound (HIFU) in combination with temperature-sensitive liposomes or genes containing a heat-inducible promoter .Author: Shao-Ling Huang, David D. McPherson
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