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https://www.fda.gov/regulatory-information/search-fda-guidance-documents/metered-dose-inhaler-mdi-and-dry-powder-inhaler-dpi-drug-products-quality-considerations
Oct 18, 2019 · Center for Drug Evaluation and Research. The purpose of this guidance is to provide recommendations to industry on the development and manufacture of inhalation aerosols (also known as metered dose inhalers (or MDIs)) and inhalation powders (also known as dry powder inhalers (or DPIs)).
https://www.sciencedirect.com/topics/neuroscience/dry-powder-inhaler
A dry powder inhaler (DPI) is a breath-actuated device that delivers the drug in the form of particles contained in a capsule or blister that is punctured prior to use. This type of inhaler requires an adequate inspiratory flow rate for drug delivery, as it does not include a propellant (Harris, 2008).
https://www.ondrugdelivery.com/choosing-right-dosator-dpi-dosing/
Most dry powder inhalers (DPIs) operate with pre-metered doses of drug formulation held in a capsule or blister pack. Dosator systems are routinely utilised for the production of these packaged doses because of their ability to deliver the requisite filling accuracy at a high throughput.
http://www.pharmtech.com/role-carriers-dpi-capsules
May 02, 2018 · Sherry Yates Young/shutterstock.com The use of capsules loaded into a dry powder inhaler (DPI) to deliver drugs to the lungs is a well-established method for the treatment of lung diseases such as asthma and chronic obstructive pulmonary disease (COPD). Developing a capsule formulation for inhalation, however, is not nearly the same as an orally administered capsule.
https://www.aarc.org/wp-content/uploads/2015/04/aerosol_guide_rt.pdf
uid (nebulizer or pMDI) or solid drug particles (pMDI or DPI) in a carrier gas. 1 Our respiratory systems evolved to have filtration and elimination systems that must be overcome or bypassed in the process of providing local delivery of
https://www.tandfonline.com/doi/full/10.1080/17425247.2016.1224846
Aug 29, 2016 · Jethaler® (Ratiopharm) and MAGhaler® (Mundipharma) are DPIs with the carrier-based drug formulation compacted by isostatic pressure technique into a ring-shaped tablet [74 Newman S, Malik S, Hirst P, et al. Lung deposition of salbutamol in healthy human subjects from the …Author: A. H. de Boer, P. Hagedoorn, M. Hoppentocht, F. Buttini, F. Grasmeijer, H. W. Frijlink
https://www.sciencedirect.com/science/article/pii/S0954611114001784
For the Diskus ®, Clickhaler ® and Elpenhaler ® FPF values of 25% of label claim were not obtained at any flow rate with the devices used to produce Fig. 4A. Attaining a pressure drop of 2–4 kPa – which is sufficient to operate most inhalers successfully and results in clinically effective drug delivery – is easier when using a high-resistance inhaler than when using a low-resistance device, independent of the …Author: Pascal Demoly, Paul Hagedoorn, Anne H. de Boer, Henderik W. Frijlink
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685506/
Dec 01, 2015 · The ELLIPTA ® DPI was developed for the delivery of once-daily therapies for the treatment of asthma and chronic obstructive pulmonary disease. It has moderate resistance to airflow and can hold one or two blister strips, with each blister containing a sealed single dose of medication.Author: Andrew C. Grant, Richard Walker, Melanie Hamilton, Karl Garrill
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334339/
Feb 12, 2015 · DPI drug formulations have greater chemical stability than liquid formulations, but manufacturing powders with the appropriate characteristics for easy aerosolization and alveolar delivery is more complicated.55 Performance of DPIs depends on the powder formulation and on the design of the inhaler device.Author: Mariam Ibrahim, Rahul Verma, Lucila Garcia-Contreras
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