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https://www.ncbi.nlm.nih.gov/pubmed/17879294
The doxorubicin-PAMAM complex led to the bioavailability that was more than 200-fold higher than that of free doxorubicin after oral administration. These results indicate that PAMAM dendrimer is a promising novel carrier to enhance the oral bioavailability of drug, especially for …Author: Weilun Ke, Yansong Zhao, Rongqin Huang, Chen Jiang, Yuanying Pei
https://www.sciencedirect.com/science/article/pii/S0144861719304953
Molecular simulation is proposed as a guidance to design an efficient oral drug delivery system. • Oral absorption of doxorubicin was remarkably enhanced by hyaluronic acid grafted fatty glyceride carriers. • The absorption improvement of doxorubicin is fatty glyceride chain length dependent.Author: Yujiao Sun, Haiyang Wu, Wei Dong, Jieyu Zhou, Xin Zhang, Lijuan Liu, Xiaofei Zhang, Hongbo Cheng, Ji...
https://link.springer.com/article/10.1007/s11095-008-9763-4
Nov 08, 2008 · Doxorubicin, a potent anticancer drug associated with cardiotoxicity and low oral bioavailability, was loaded into nanoparticles with a view to improve its performance. Doxorubicin loaded PLGA nanoparticles were prepared by a double emulsion method. The pH dependent stability of nanoparticles in simulated fluids was evaluated. DSC and XRD studies were carried out in order to …Author: D. R. Kalaria, G. Sharma, V. Beniwal, M. N. V. Ravi Kumar
https://www.sciencedirect.com/science/article/pii/S0141813018337061
We have prepared casein nanoparticles loaded with an anticancer drug doxorubicin, which was shown to be an effective drug delivery vehicle at physiological as well as acidic pH. The system gave comparatively higher release in acidic pH, giving it the potential to be used …Author: Sona Gandhi, Indrajit Roy
https://www.ncbi.nlm.nih.gov/pubmed/22871060
Sep 04, 2012 · Oral delivery of doxorubicin using novel polyelectrolyte-stabilized liposomes (layersomes). Jain S(1), Patil SR, Swarnakar NK, Agrawal AK. Author information: (1)Centre for Pharmaceutical Nanotechnology, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Sector 67, SAS Nagar (Mohali) Punjab-160062, India ...Author: Sanyog Jain, Swapnil R. Patil, Nitin K. Swarnakar, Ashish K. Agrawal
https://www.rxlist.com/consumer_doxorubicin_adriamycin/drugs-condition.htm
Warnings. Doxorubicin should be administered under the supervision of an experienced cancer chemotherapy physician; Cumulative dose-related cardiotoxicity may occur. Potentially fatal congestive heart failure (CHF) may occur months to years after completion of therapy.The risk of developing CHF increases with increasing total cumulative doses of doxorubicin in excess of 450 mg/m²
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