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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604883/
Dec 10, 2008 · Intranasal delivery provides a practical, non-invasive method of bypassing the blood-brain barrier (BBB) to deliver therapeutic agents to the brain and spinal cord. This technology allows drugs that do not cross the BBB to be delivered to the central ...Author: Leah R Hanson, William H Frey, William H Frey
http://intranasal.net/Peer%20Reviewed%20literature/Talegaonkar,%20Intranasal%20delivery%20-%20An%20approach%20to%20bypass%20the%20blood%20brain%20barrier,%20I%20J%20Pharm%202004.pdf
Intranasal delivery: An approach to bypass the blood brain barrier S. Talegaonkar, P. R. Mishra ABSTRACT The blood brain barrier (BBB) represents one of the strictest barriers of in vivo therapeutic drug delivery. The barrier is defined by restricted exchange of hydrophilic compounds, small proteins
https://www.celerion.com/wp-content/uploads/2015/05/Celerion_050515_TIDES_Intranasal-Drug-Delivery.pdf
(2012) Drug development of intranasally delivered peptides. Therapeutic Delivery 3(4), 557-568 Dhuria SV, Hanson LR, Frey WH, 2nd (2010) Intranasal delivery to the central nervous system: mechanisms and experimental considerations. J Pharm Sci 99(4), 1654-1673 Merkus FW, Van Den Berg MP (2007) Can nasal drug delivery
http://intranasal.net/Overview/default.htm
Drug volume discussion. The volume of drug administered is a poorly studied but important clinical concept for those who are interested in a deeper understanding of intranasal medication delivery and the pharmaceutical/FDA approach to dosing and concentration versus the approach of clinicians who just want to help their patients.
https://www.sciencedirect.com/science/article/pii/S0168365916301079
Enhanced intranasal delivery of mRNA vaccine by overcoming the nasal epithelial barrier via intra- and paracellular pathways. ... cilia movement may accelerate the clearance of mRNA antigen and shorten its nasal residence time, resulting in poor antigen uptake. Although the nasal cavity contains APCs, the nasal epithelium presents a major ...Author: Man Li, Mengnan Zhao, Yao Fu, You Li, Tao Gong, Zhirong Zhang, Xun Sun
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653240/
Apr 08, 2013 · Intranasal administration is a method of delivering therapeutic agents to the central nervous system (CNS). It is non-invasive and allows large molecules that do not cross the blood-brain barrier access to the CNS. Drugs are directly targeted to the CNS with intranasal delivery, reducing systemic exposure and thus unwanted systemic side effects 1.Author: Leah R. Hanson, Jared M. Fine, Aleta L. Svitak, Katherine A. Faltesek
http://www.mysticpharmaceuticals.com/IntranasalDrugDeliverySpecialReport.pdf
Advantages of Transnasal Drug Delivery One distinct advantage of transnasal drug delivery is that drug uptake into the blood circulatory system by absorption through the nasal mucosa can be quite rapid. 1,2 An aerosol containing a biologically active agent can produce its effect very rapidly.3 Transnasal drug delivery may be the
http://intranasal.net/Peer%20Reviewed%20literature/Pires,%20Intranasal%20drug%20delivery%20-%20How%20why%20%20what%20for%20-extensive%20review,%20J%20Pharm%20Pharmaceut%20Sci%202009.pdf
J Pharm Pharmaceut Sci (www.cspsCanada.org) 12(3) 288 - 311, 2009 288 Intranasal Drug Delivery: How, Why and What for? Anaísa Pires 1,2, Ana Fortuna , Gilberto Alves2,3 and Amílcar Falcão1,2 1 Pharmacology Department, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.2 Centre for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal.
http://intranasal.net/DeliveryTechniques/default.htm
A second method of intranasal drug delivery is to take a solubilized medication (liquid form) and drip it into the nose a few drops at a time, allowing it to run down onto the nasal mucosa. This can be done using a syringe or in some instances using the packaged form …
https://bmcneurosci.biomedcentral.com/articles/10.1186/1471-2202-9-S3-S5
Dec 10, 2008 · Intranasal delivery provides a practical, non-invasive method of bypassing the blood-brain barrier (BBB) to deliver therapeutic agents to the brain and spinal cord. This technology allows drugs that do not cross the BBB to be delivered to the central nervous system within minutes. It also directly delivers drugs that do cross the BBB to the brain, eliminating the need for systemic ...Author: Leah R Hanson, William H Frey, William H Frey
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