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https://www.sciencedirect.com/science/article/pii/S0167779915001614
Tailored DNA-based assemblies can be used as advanced drug-delivery vehicles in various therapeutic applications. DNA nanodevices can target cells and trigger single-molecule level reactions in biological environment. Functional DNA nanostructures can serve as versatile molecular machines and preprogrammed templates in cells.Author: Veikko Linko, Ari Ora, Mauri A. Kostiainen
https://pubs.acs.org/doi/10.1021/acs.chemrev.7b00663
Over the past decade, we have seen rapid advances in applying nanotechnology in biomedical areas including bioimaging, biodetection, and drug delivery. As an emerging field, DNA nanotechnology offers simple yet powerful design techniques for self-assembly of nanostructures with unique advantages and high potential in enhancing drug targeting and reducing drug toxicity.Author: Qinqin Hu, Hua Li, Lihua Wang, Lihua Wang, Hongzhou Gu, Chunhai Fan, Chunhai Fan
https://wyss.harvard.edu/technology/dna-nanostructures-for-drug-delivery/
Customizable nanostructures that can be precisely programmed for different applications. Researchers at the Wyss Institute have developed two methods for building arbitrarily shaped nanostructures using DNA, with a focus on translating the technology towards nanofabrication and drug delivery applications.
https://www.drugtargetreview.com/news/43600/dna-nanostructures-drug-delivery-challenge/
May 13, 2019 · This is according to researchers at McGill University.In a paper published in the American Chemical Society journal ACS Central Science, the McGill scientists demonstrate that many DNA cage nanostructures aren’t taken up by cells to a significant extent. In a series of experiments, they show, instead, that the DNA nanostructures are degraded by enzymes outside the cell; a fluorescent dye ...
https://www.sciencedaily.com/releases/2020/03/200309152051.htm
Mar 09, 2020 · Protecting DNA origami for anti-cancer drug delivery ... have designed and synthesized chains of molecules with a precise sequence and length to efficiently protect 3-D DNA …
https://pubs.rsc.org/en/content/articlelanding/2020/nr/c9nr08519j
Herein, we present the modular design and assembly of functional DNA nanostructures through sequence-specific interactions between zinc-finger proteins (ZnFs) and DNA as a cytosolic drug delivery platform. Three kinds of DNA-binding ZnF domains were genetically fused to various proteins with different biological roles, including targeting ...Author: Yiseul Ryu, Cheol Am Hong, Yunjin Song, Jonghwi Beak, Bo Am Seo, Joong-jae Lee, Hak-Sung Kim
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997790/
Jan 28, 2020 · Abundant advantages make DNA nanostructures an ideal platform to deliver immune drugs, including CpG ODNs and other immunostimulatory agents, to target locations. Drug delivery systems based on various DNA nanostructure been proposed …Author: Qingjia Chi, Zichang Yang, Kang Xu, Chunli Wang, Huaping Liang
https://www.researchgate.net/publication/318975568_DNA_Tetrahedron_Nanostructures_for_Biological_Applications_Biosensors_and_Drug_Delivery
DNA Tetrahedron Nanostructures for Biological Applications: Biosensors and Drug Delivery Article (PDF Available) in The Analyst 142(18) · August 2017 with 168 Reads How we measure 'reads'
https://pubs.acs.org/doi/abs/10.1021/acs.biochem.5b01181
DNA self-assembling nanostructure has been considered as a promising candidate as a drug delivery vehicle because of its compactness, mechanical stability, and noncytotoxicity. In this work, we developed functional, multiform DNA nanostructures by appending a tumor-penetrating peptide to tetrahedral DNA nanostructure (p-TDN). This functional structure is able to efficiently increase the rate ...Author: Zhiwei Xia, Ping Wang, Xunwei Liu, Ting Liu, Yinan Yan, Juan Yan, Jian Zhong, Gang Sun, Dannong He
https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.201804785
In particular, DNA‐origami nanostructures feature rationally designed geometries and precise spatial addressability, as well as marked biocompatibility, thus providing a promising candidate for drug delivery. Here, the recent successful efforts to employ self‐assembled DNA‐origami nanostructures as drug‐delivery vehicles are summarized.Author: Qiao Jiang, Shaoli Liu, Shaoli Liu, Jianbing Liu, Zhen‐Gang Wang, Baoquan Ding, Baoquan Ding, Baoqua...
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