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https://www.sciencedirect.com/science/article/pii/S0378517313010351
Non-viral DNA delivery systems are classed into two groups:-Physical methods: DNA is delivered into its target without using any carrier, by using physical forces to weaken the membrane cell to make it more permeable to the transgene (Gao et al., 2007).-Author: D. Ibraheem, A. Elaissari, H. Fessi
https://pubs.acs.org/doi/10.1021/acs.chemrev.7b00663
Over the past decade, we have seen rapid advances in applying nanotechnology in biomedical areas including bioimaging, biodetection, and drug delivery. As an emerging field, DNA nanotechnology offers simple yet powerful design techniques for self-assembly of nanostructures with unique advantages and high potential in enhancing drug targeting and reducing drug toxicity.Author: Qinqin Hu, Hua Li, Lihua Wang, Lihua Wang, Hongzhou Gu, Chunhai Fan, Chunhai Fan
http://www.nature.com/articles/nbt0100_33
Jan 01, 2000 · Over the past 30 years, DNA delivery, especially via the nonviral route (i.e., transfection), has become a powerful and popular research tool for elucidating gene structure, regulation, and function.Author: Dan Luo, W. M. Saltzman
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465129/
This was among the first infectious disease DNA vaccine to be delivered in humans using electroporation-based DNA delivery. In addition DNA vaccine delivery by electroporation is being investigated in many cancers such as prostrate cancer, metastatic melanoma and is under clinical trials.
https://www.sciencedirect.com/science/article/pii/S0169409X1930208X
Delivery systems need to bind and condense CRISPR-Cas systems into small sizes or encapsulate them. In addition, delivery systems that can overcome in vivo barriers, including nuclease degradation, immunogenicity, selective cell targeting and nuclear envelope obstacles, can greatly enhance genome editing efficiency and reduce off-target risks ...Author: Cong-Fei Xu, Guo-Jun Chen, Ying-Li Luo, Yue Zhang, Gui Zhao, Zi-Dong Lu, Anna Czarna, Zhen Gu, Jun W...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417261/
Mar 12, 2019 · A new non-viral DNA delivery vectors of the terplex systems and polyethylene glycol-grafted poly(L-lysine) as polymeric gene carriers were also developed for gene delivery systems [102–105]. The clinical evaluations have currently made in the field of biomedical applications [106–117].Author: YK Sung, SW Kim
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · INTRODUCTION. Basically gene therapy is an intracellular delivery of genomic materials (transgene) into specific cells to generate a therapeutic effect by correcting an existing abnormality or providing the cells with a new function.[] Different types of gene delivery systems may be applied in gene therapy to restore a specific gene function or turning off a special gene(s).
https://www.thermofisher.com/us/en/home/references/gibco-cell-culture-basics/transfection-basics/selecting-a-viral-dna-delivery-system.html
Selecting a Viral DNA Delivery System. ... ViraPower™ Expression Systems from Life Technologies™ use replication-incompetent viral particles to ensure safe and highly-efficient delivery of expression constructs for high-level constitutive or inducible expression in any mammalian cell type. A number of vectors available for use with the ...
https://dnaenergetics.com/
The varying delivery systems for each blend are specially designed to enhance their therapeutic effects. For blends available by way of topical application, the oil can be applied directly on the skin for absorption into the body. Alternatively, some oils are available for inhalational delivery.
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