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https://www.sciencedirect.com/science/article/pii/S0378517313010351
Therefore DNA must be associated with the delivery system or vector that carries the therapeutic gene into the targeted cell, protecting it from degradation by nucleases (Nam et al., 2009, Gardlík et al., 2005), and making sure that it transcribes inside the cell (Gardlík et al., 2005).Author: D. Ibraheem, A. Elaissari, H. Fessi
http://www.nature.com/articles/nbt0100_33
Jan 01, 2000 · Over the past 30 years, DNA delivery, especially via the nonviral route (i.e., transfection), has become a powerful and popular research tool for elucidating gene structure, regulation, and function.Author: Dan Luo, W. M. Saltzman
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417261/
Mar 12, 2019 · In somatic gene delivery system, there are three types such as in vivo delivery, ex vivo delivery and in situ delivery. In vivo delivery systems, the genetic materials transfer directly into the targeting tissue. In ex vivo delivery system, the genetic materials implant into the targeting tissue bone marrow, cultivated, and manipulated in vitro.Author: YK Sung, SW Kim
https://pubs.acs.org/doi/pdf/10.1021/nn3022662
DNA Origami Delivery System for Cancer Therapy with Tunable Release Properties Yong-XingZhao,†,‡ AlanShaw, †XianghuiZeng, ErikBenson, †AndreasM.Nystro¨m,andBjo¨rnHo¨gberg†,* †Swedish Medical Nanoscience Center, Department of Neuroscience, Karolinska Institute, SE-171 77 Stockholm, Sweden, and ‡School of Pharmaceutical Sciences,
https://www.thermofisher.com/us/en/home/references/gibco-cell-culture-basics/transfection-basics/selecting-a-viral-dna-delivery-system.html
Selecting a Viral DNA Delivery System. ... There are many options in selecting a viral delivery system matched to your specific needs. Life Technologies™ offers a variety of viral vector systems for delivering nucleic acids into mammalian and insect cells for protein expression and RNAi studies.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687232/
Nov 27, 2012 · An ideal nonviral gene carrying system should possess all these merits without any compromise to its gene transferring efficiency. The viral gene delivery systems include lytic and nonlytic vectors for drug delivery. Inspite of its toxicity they are still preferred because of their long term expression, stability, and integrity.
https://biocyclopedia.com/index/agriculture_biotechnology/dna_delivery_systems.php
DNA delivery systems Agrobacterium tumefaciens This bacterium is a natural transformer of somatic host cells of plants into tumorous crown gall cells. Its ability to transform cells with a piece of DNA was exploited by plant biologists, and now Agrobacterium plays a prominent role in transgenesis of plants. This natural gene transfer system is ...
https://www.technologynetworks.com/biopharma/blog/a-new-system-for-dnarna-delivery-in-cancer-therapeutics-332270
The surface is coated with a charged molecule, PEI, which attracts and binds DNA/RNA. This simply and effectively traps and protects mRNA/pDNA before it has time to enter the target cells. Once inside the cell, the DNA/RNA is released to produce the antigenic …
https://www.inovio.com/technology/
Inovio Technology Platform. Inovio's proprietary platform is leading the way forward for activation immunotherapy. This one-of-a-kind platform delivers optimized DNA into cells, where it is translated into proteins that activate an individual's immune system to generate a robust targeted T …
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