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https://www.sciencedirect.com/science/article/pii/S0168365999000930
Diffusion-controlled drug delivery systems: calculation of the required composition to achieve desired release profiles 1. Introduction. Diffusion is the most important mechanism used to control drug release... 2. Experimental. The following chemicals were obtained from commercial suppliers... 3. ...Author: J Siepmann, F Lecomte, R Bodmeier
https://link.springer.com/chapter/10.1007%2F978-1-4614-0881-9_6
Sep 27, 2011 · Abstract. This chapter presents an overview on the different types of drug delivery systems that are predominantly governed by diffusion. The systems are classified according to their physical structure (reservoir devices versus monolithic systems), as well as according to the ratio of “initial drug loading and drug solubility.” For various cases,...Author: Juergen Siepmann, Ronald A. Siegel, Florence Siepmann
https://www.researchgate.net/publication/278662176_Diffusion_Controlled_Drug_Delivery_Systems
Hydrogels are extensively studied as matrices for the controlled release of macromolecules. To evaluate the mobility of embedded molecules, these drug delivery systems are usually characterized by release studies. However, these experiments are time-consuming and their reliability is often poor.
https://www.hansvanlaarhoven.nl/diffusion-based-delivery/
The drug delivery from a diffusion based delivery system can be simulated using the transport of diluted species module in Comsol Multiphysics™. In order to predict how fast the drug diffuses from the active layer to a dissolution vessel or a physiological body, the compartments of the drug delivery system have to be defined in Comsol Multiphysics™, each with their specific solubility and diffusivity parameters.
https://www.researchgate.net/publication/284254926_Diffusion-controlled_drug_delivery_systems
Hydrophilic matrix systems are polymer-based drug delivery systems in which two competing mechanisms are involved in the drug release: Fickian diffusional release, and relaxational release.
http://www.thepharmajournal.com/vol1Issue10/Issue_dec_2012/3.1.pdf
Diffusion controlled release7 Reservoir type devices Matrix type devices 3. Diffusion and Dissolution controlled systems Ion exchange resins 5. ½ of a drug the larger will be the fluctuations between the maximum steady state concentration and maximum steady state concentration upon repetitive dosing.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142099/
Sep 28, 2014 · The controlled drug delivery technology has progressed over the last six decades. It began in 1952 with the introduction of the first sustained release formulation. The 1st generation (1950-1980) of drug delivery was focused on developing oral and transdermal sustained release systems and establishing the controlled drug release mechanisms.Author: Kinam Park
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