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https://www.sciencedirect.com/science/article/pii/016836599500049E
Novel hydrogels based on dextran crosslinked with diisocyanate have been proposed for colon-specific drug delivery. The hydrogels have been characterized by …Author: Lars Hovgaard, Helle Brøndsted
https://www.sciencedirect.com/science/article/pii/0928098795000236
In the present study degradation of dextran hydrogels, potential drug carriers for colon-specific drug delivery, was studied in simulated small intestinal juices as well as in a …Author: Lene Simonsen, Lars Hovgaard, Per Brøbech Mortensen, Helle Brøndsted
https://www.dextran.com/about-dextran/literature/delivery
Synthesis and characterization of pH-sensitive dextran hydrogels as a potential colon-specific drug delivery system Hsin-Cheng Chiu, Ging-Ho Hsiue, Yang-Ping Lee & Liang-Wei Huang Journal of Biomaterials Science, Polymer Edition, Volume 10, Issue 5, 1999 Link to article
https://pubs.acs.org/doi/abs/10.1021/acsami.6b00959
Severe side effects of cancer chemotherapy prompt developing better drug delivery systems. Injectable hydrogels are an effective site-target system. For most of injectable hydrogels, once delivered in vivo, some properties including drug release and degradation, which are critical to chemotherapeutic effects and safety, are challenging to monitor.Author: Jia Liu, Chao Qi, Kaixiong Tao, Jinxiang Zhang, Jian Zhang, Luming Xu, Xulin Jiang, Yunti Zhang, Lei...
https://www.tandfonline.com/doi/abs/10.1163/156856299X00504
(1999). Synthesis and characterization of pH-sensitive dextran hydrogels as a potential colon-specific drug delivery system. Journal of Biomaterials Science, Polymer Edition: Vol. 10, No. 5, pp. 591-608.Author: Hsin-Cheng Chiu, Ging-Ho Hsiue, Yang-Ping Lee, Liang-Wei Huang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178968/
Dextran hydrogels degraded in vivo in the cecum of rats but not in the stomach suggesting that dextran hydrogels can be used as drug carriers for colon-specific drug delivery. McLeod et al .[ 27 ] synthesized glucocorticoid-dextran conjugates in which dexamethasone and methylprednisolone were attached to dextran using dicarboxylic acid linkers ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215502/
Feb 07, 2010 · Introduction. Targeted drug delivery into the colon is highly desirable for local treatment of a variety of bowel diseases such as ulcerative colitis, Crohn’s disease, amebiosis, colonic cancer, local treatment of colonic pathologies, and systemic delivery of protein and peptide drugs.1, 2 The colon specific drug delivery system (CDDS) should be capable of protecting the drug en route to the ...Author: Anil K. Philip, Betty Philip
https://www.oatext.com/Polysaccharides-in-colon-specific-drug-delivery.php
Major polysaccharides involved in colon specific drug delivery system. Many natural polysaccharides such as chondroitin sulphate, pectin, dextran and more particularly guar gum, etc. has started with basis of investigation for their potential in innovating colon specific drug delivery.
https://www.researchgate.net/publication/229094129_Synthesis_and_characterization_of_superparamagnetic_chitosan-dextran_sulfate_hydrogels_as_nano_carriers_for_colon-specific_drug_delivery
Synthesis and characterization of superparamagnetic chitosan–dextran sulfate hydrogels as nano carriers for colon-specific drug delivery Article (PDF Available) in Carbohydrate Polymers 81(2 ...
https://www.researchgate.net/scientific-contributions/72814408_L_Simonsen
In the present study degradation of dextran hydrogels, potential drug carriers for colon-specific drug delivery, was studied in simulated small intestinal juices as well as in a human colonic ...
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