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https://www.ncbi.nlm.nih.gov/pubmed/22432550
INTRODUCTION: Dextran is a family of natural polysaccharides that is widely under investigation for use as polymeric carriers in novel drug delivery systems. The optimal drug delivery (and consequently maximum therapeutic effect) will be accomplished when carrier systems are used mainly for drugs with antitumoral activity, as they increase ...Author: Jaleh Varshosaz
https://www.sigmaaldrich.com/catalog/papers/22432550
Dextran is a family of natural polysaccharides that is widely under investigation for use as polymeric carriers in novel drug delivery systems. The optimal drug delivery (and consequently maximum therapeutic effect) will be accomplished when carrier systems are used mainly for drugs with antitumoral activity, as they increase their blood ...
https://www.tandfonline.com/doi/full/10.1517/17425247.2012.673580
Apr 19, 2016 · Introduction: Dextran is a family of natural polysaccharides that is widely under investigation for use as polymeric carriers in novel drug delivery systems. The optimal drug delivery (and consequently maximum therapeutic effect) will be accomplished when carrier systems are used mainly for drugs with antitumoral activity, as they increase their blood permanence time, taking advantage of the ...Author: Jaleh Varshosaz
https://www.sciencedirect.com/science/article/pii/S014296121300851X
Water-insoluble acetalated dextran was prepared by modifying water-soluble dextran with acid-labile acetal moieties. We hypothesized that nanoparticles made of Boronate–Dextran polymer (B-Dex), dextran modified with phenylboronic acid, could show pH-responsive dissolution and, therefore, could be used for targeted drug delivery applications.Author: Linxian Li, Linxian Li, Zewei Bai, Pavel A. Levkin, Pavel A. Levkin
https://www.ncbi.nlm.nih.gov/pubmed/23932249
Here we describe an approach to functionalize vicinal diols of dextran with hydrophobic boronate esters in order to produce a water insoluble boronate dextran polymer (B-Dex), which spontaneously forms acid-responsive nanoparticles in water. We show the encapsulation of a hydrophobic anticancer drug doxorubicin into the particles.Author: Linxian Li, Linxian Li, Zewei Bai, Pavel A. Levkin, Pavel A. Levkin
https://www.sciencedirect.com/science/article/pii/S0141813019364189
Targeted drug delivery system (TDDS) is a drug controlled release system, also known as targeted preparations, which can selectively act on target organs, target tissues and target cells [, , ].Another hotspot of dextran research is its application in drug carriers.Author: Fang Chen, Gangliang Huang, Hualiang Huang
https://pubs.acs.org/doi/abs/10.1021/acsami.6b00959
Severe side effects of cancer chemotherapy prompt developing better drug delivery systems. Injectable hydrogels are an effective site-target system. For most of injectable hydrogels, once delivered in vivo, some properties including drug release and degradation, which are critical to chemotherapeutic effects and safety, are challenging to monitor.Author: Jia Liu, Chao Qi, Kaixiong Tao, Jinxiang Zhang, Jian Zhang, Luming Xu, Xulin Jiang, Yunti Zhang, Lei...
https://www.dextran.com/about-dextran/literature/delivery
Synthesis and characterization of pH-sensitive dextran hydrogels as a potential colon-specific drug delivery system Hsin-Cheng Chiu, Ging-Ho Hsiue, Yang-Ping Lee & Liang-Wei Huang Journal of Biomaterials Science, Polymer Edition, Volume 10, Issue 5, 1999 Link to article
https://www.researchgate.net/publication/331682236_Preparation_and_drug_delivery_of_dextran-drug_complex
Mar 11, 2019 · Dextran as a drug carrier for inhibiting cancer cells effectively reduces the toxic and side effects of the drug in the biological body. Targeting improves the concentration of active substance ...
https://web.wpi.edu/Pubs/E-project/Available/E-project-042506-120742/unrestricted/Drug_Delivery_Final_MQP_2006.pdf
An ideal drug delivery method releases the drug through zero order kinetics, resulting in a slower, more controlled drug release and a steady concentration of drug within the body. Controlled drug release helps to guard against toxicity problems because it prevents the initial spike of the drug substance that occurs with uncontrolled
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