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https://www.sciencedirect.com/science/article/pii/S0002939409000026
Dexamethasone DDS = Dexamethasone posterior segment drug delivery system. a. Adverse events reported in at least 5% of patients in any group at any time during the study and for which the among-group P value was statistically significant; only randomized patients who received treatment were included in the safety analysis.Author: George A. Williams, Julia A. Haller, Baruch D. Kuppermann, Mark S. Blumenkranz, David V. Weinberg, C...
http://www.io.nihr.ac.uk/wp-content/uploads/migrated/2237.bf72cc98.Dexamethasone_June12.pdf
Dexamethasone posterior segment drug delivery system (DEX PS DDS, Ozurdex) is an implant injected into the vitreous that delivers dexamethasone to the posterior segment of the eye. Corticosteroids have been shown to inhibit the expression of VEGF and other pro-inflammatory mediators
https://www.sciencedirect.com/science/article/pii/S1773224718301813
Drug delivery to the eye can therefore broadly be classified into drug delivery to the anterior segment and drug delivery to the posterior segment. Topical administration, for example in the form of eye drops, suspension or ointments, is the preferred non-invasive route of drug delivery to treat diseases affecting the anterior segment.Author: Sunna Johannsdottir, Phatsawee Jansook, Einar Stefansson, Iris Myrdal Kristinsdottir, Zoltan Fulop, ...
https://www.aao.org/eyenet/article/drug-delivery-for-the-posterior-segment
A Legacy of Innovation. Today’s innovations are part of a pioneering legacy in research for vitreoretinal diseases. Dr. Grewal points to Vitrasert (Chiron, later Bausch + Lomb), the first sustained-release posterior segment drug delivery system that laid some of the foundation for today’s breakthroughs.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441033/
Context: Dexamethasone Posterior-Segment Drug Delivery System is a novel, biodegradable, sustained-release drug delivery system (OZURDEX ®) for treatment of macular edema following retinal vein occlusion and posterior uveitis.However, its potential role in management of diabetic macular edema has not been reported yet.
https://www.retinalphysician.com/issues/2007/september-2007/drug-delivery-to-the-posterior-segment
Sep 01, 2007 · PEER REVIEWED Drug Delivery to the Posterior Segment DARYL E. KURZ, MD · THOMAS A. CIULLA, MD. Intravitreal pegaptanib sodium (Macugen, OSI/Pfizer) and intravitreal ranibizumab (Lucentis, Genentech) received Food and Drug Administration (FDA) approval for the treatment of neovascular age-related macular degeneration (AMD) in 2004 and 2006, respectively.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000767/
Dec 06, 2010 · Williams GA, Haller JA, Kupperman BD, et al. Dexamethasone DDS Phase II Study Group. Dexamethasone Posterior-Segment Drug Delivery System in the treatment of macular edema resulting from uveitis or Irvine-Gass syndrome. Am J Ophthalmol. 2009; 147:1048–1054.Author: Jane S Myung, Grant D Aaker, Szilárd Kiss
https://www.tandfonline.com/doi/pdf/10.1080/10717544.2016.1264498
concentration could be sustained moderately higher in the posterior segment by CCSDD than SC and IV, indicating that CCSDD might be a therapeutic alternative to treat a variety of intractable posterior segment diseases. Keywords Dexamethasone, sub-tenon drug delivery, posterior segment, rabbit eye, topical administration, pharmacokinetics HistoryAuthor: Xuetao Huang, Shaogang Liu, Yezhen Yang, Yiqin Duan, Ding Lin
https://clinicaltrials.gov/ct2/show/NCT00168389
Sep 15, 2005 · A Study of the Safety and Efficacy of a New Treatment for Diabetic Macular Edema. ... 700 µg Dexamethasone posterior segment drug delivery system - injection into the vitreous cavity not less than every 6 months for up to 36 months. ... Sham posterior segment drug delivery system - needle-less drug delivery system without study medication not ...
https://www.oraclinical.com/resource/the-renaissance-of-drug-delivery-systems-for-the-posterior-segment/
Drug delivery to the posterior segment is hampered by the anatomy of the eye due to its inherent design, which dilutes and removes foreign material. In topically administered treatments, more than 90% of the drug from an eye drop will be lost before making it past the tear film.
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