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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539067/
Oct 18, 2012 · Metered-dose spray pumps. Metered spray pumps have, since they were introduced some four decades ago, dominated the nasal drug delivery market (Table 1). The pumps typically deliver 100 μl (25–200 μl) per spray, and they offer high reproducibility of the emitted dose and plume geometry in in vitro tests.Author: Per Gisle Djupesland
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762624/
Nasal spray is a unique drug delivery means that has been widely used to deliver medication to the intranasal cavity to treat numerous topical diseases such as allergic rhinitis, sinusitis, and nasal congestion for those suffering from the common cold.Author: Tina Masiuk, Parul Kadakia, Zhenyu Wang
https://www.nextbigfuture.com/2013/05/nasal-spray-gene-therapy-could-protect.html
James Wilson, a leading gene therapy researcher at the University of Pennsylvania, credits the idea to a meeting with Bill Gates in April 2010. Wilson had studied whether a harmless gene therapy tool called adeno-associated virus (AAV) can serve as a gene delivery vehicle to treat inherited diseases like cystic fibrosis and hemophilia.
https://quizlet.com/99962018/medical-test-2122-flash-cards/
development of a nasal spray that contains copies of the normal gene that is defective in persons with cystic fibrosis.
https://www.researchgate.net/publication/333023092_Development_of_Inhalable_Dry_Gene_Powders_for_Pulmonary_Drug_Delivery_by_Spray-Freeze-Drying
In this review, we aim to provide an overview about the potentials of spray-freeze-drying (SFD) for the development of inhalable dry gene powders for pulmonary drug delivery.
https://www.scientific.net/AMR.194-196.541
Feb 01, 2011 · Chitosan nanoparticles were prepared by crosslinking chitosan (CS) with tripolyphosphate (TPP) solution using electrohydrodynamic spraying technique. The effects of CS and TPP concentration as well as electrical potential on particle size and shape were investigated. Appropriated formulations for preparing nanoparticles were chosen to encapsulate DNA.Author: Orapan Paecharoenchai, Tittaya Suksamran, Tanasait Ngawhirunpat, Theerasak Rojanarata, Praneet Opana...
https://www.slideshare.net/yasminabdelaziz/nasal-spray-development-and-manufacturing-1
Mar 02, 2012 · SOLUTIONEnsuring a Streamlined In the pre‐formulation and formulation stages of Approach for Nasal Spray development, the physical characterization of nasal aerosol drug products must include a thorough examination of: Product Development & Solubility and particle characteristics Manufacturing API / excipient compatibility Plume characterization: Spray pattern, plume geometry and spray droplet size Spray content uniformity INTRODUCTION Container closure testing…
https://www.researchgate.net/publication/40821284_Development_of_a_nasal_adenovirus-based_vaccine_Effect_of_concentration_and_formulation_on_adenovirus_stability_and_infectious_titer_during_actuation_from_two_delivery_devices
Download Citation Development of a nasal adenovirus-based vaccine: Effect of concentration and formulation on adenovirus stability and infectious titer during actuation from two delivery devices ...
https://www.sciencedirect.com/science/article/pii/S0168365916301079
Facing the threat of highly variable virus infection, versatile vaccination systems are urgently needed. Intranasal mRNA vaccination provides a flexible and convenient approach. However, the nasal epithelium remains a major biological barrier to deliver antigens to nasal associated lymphoid tissue …Author: Man Li, Mengnan Zhao, Yao Fu, You Li, Tao Gong, Zhirong Zhang, Xun Sun
https://quizlet.com/100077717/test-2-pltw-mi-flash-cards/
Development of a nasal spray that contains copies of the normal gene that is defective in persons with cystic fibrosis If a restriction enzyme were to cut a strand of DNA three times, how many RFLPs would show up on the gel Electrophoresis?
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