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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539067/
Oct 18, 2012 · Metered-dose spray pumps. Metered spray pumps have, since they were introduced some four decades ago, dominated the nasal drug delivery market (Table 1). The pumps typically deliver 100 μl (25–200 μl) per spray, and they offer high reproducibility of the emitted dose and plume geometry in in vitro tests.Author: Per Gisle Djupesland
https://www.sciencedirect.com/science/article/pii/S1359644602025291
Consequently, drug delivery companies are actively pursuing the development of novel nasal drug-delivery systems and the exploitation of these for administration of conventional generic drugs and peptides, both in-house and with partners in the pharmaceutical industry.Author: Lisbeth Illum
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762624/
Nasal spray is a unique drug delivery means that has been widely used to deliver medication to the intranasal cavity to treat numerous topical diseases such as allergic rhinitis, sinusitis, and nasal congestion for those suffering from the common cold.Author: Tina Masiuk, Parul Kadakia, Zhenyu Wang
https://www.optinose.com/wp-content/uploads/2012/10/Nasal-drug-delivery-devices-characteristics-and-performance-in-a-clnical-perspective-Review-Oct-2012.pdf
Nasal drug delivery devices: characteristics and performance in a clinical perspective—a review Per Gisle Djupesland # The Author(s) 2012. This article is published with open access at Springerlink.com Abstract Nasal delivery is the logical choice for topical treatment of local diseases in the nose and paranasal sinuses
https://www.slideshare.net/yasminabdelaziz/nasal-spray-development-and-manufacturing-1
Mar 02, 2012 · SOLUTIONEnsuring a Streamlined In the pre‐formulation and formulation stages of Approach for Nasal Spray development, the physical characterization of nasal aerosol drug products must include a thorough examination of: Product Development & Solubility and particle characteristics Manufacturing API / excipient compatibility Plume characterization: Spray pattern, plume geometry and spray droplet size Spray content uniformity INTRODUCTION Container closure testing…
https://quizlet.com/99962018/medical-test-2122-flash-cards/
development of a nasal spray that contains copies of the normal gene that is defective in persons with cystic fibrosis.
http://intranasal.net/DeliveryTechniques/default.htm
Syringe dropper "technique" Squeeze bottle delivery. Squeeze bottle delivery is another option for nasal drug delivery. However this technique is not able to deliver a measure dose of drug. Mucosal coverage is also dependent on the patient applying adequate pressure to the device to deliver the drug - so delivery is very variable.
https://en.wikipedia.org/wiki/Nasal_administration
Drugs for nasal administration. The area of intranasal medication delivery provides a huge opportunity for research – both for specifically developed pharmaceutical drugs designed for intranasal treatment, as well as for investigating off label uses of commonly available generic medications. Nasal sprays for local effect are quite common. Steroids, antiasthma medications such as salbutamol, ipratropium, montelukast and a large number of inhalational anaesthetic agents …
https://www.researchgate.net/publication/253648700_Delivery_systems_for_gene_therapy
Delivery systems for gene therapy. ... Other techniques such as suicide gene therapy, use of oncolytic viruses or the use of antisense RNA have shown positive although very preliminary results ...Author: Shrikant Mali
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