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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706875/
Nov 07, 2017 · In order to improve the dissolution and oral bioavailability of valsartan (VST), and reduce the required volume for treatment, we previously formulated a supersaturable self-microemulsifying drug delivery system (SuSMEDDS) composed of VST (80 mg), Capmul ® MCM (13.2 mg), Tween ® 80 (59.2 mg), Transcutol ® P (59.2 mg), and Poloxamer 407 (13.2 mg). In the present study, by using …Author: Dong Woo Yeom, Bo Ram Chae, Jin Han Kim, Jun Soo Chae, Dong Jun Shin, Chang Hyun Kim, Sung Rae Kim, ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513451/
The present studies entail formulation development of novel solid self-nanoemulsifying drug delivery systems (S-SNEDDS) of valsartan with improved oral bioavailability, and evaluation of their in vitro and in vivo performance. Preliminary solubility studies were carried out and pseudoternary phase diagrams were constructed using blends of oil (Capmul MCM), surfactant (Labrasol), and ...Author: Sarwar Beg, Suryakanta Swain, Harendra Pratap Singh, Ch Niranjan Patra, Me Bhanoji Rao
https://journal.pda.org/content/60/6/343
Nov 01, 2006 · A self-microemulsifying drug delivery system (SMEDDS) for enhancement of oral absorption of a poor water-soluble drug, α-Asarone (ARE), is reported. Solubility of ARE was determined in various vehicles. SMEDDS consisted of a mixture of oils, surfactants, and cosurfactants that were emulsified in an aqueous medium under the gentle agitation and digestive motility. Pseudo-ternary …Author: Dong Kai Wang, Zhao Hui Shi, Lai Liu, Xiao Yan Wang, Cui Xia Zhang, Peng Zhao
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/self-microemulsifying-drug-delivery-system
Microemulsions, self-microemulsifying drug delivery systems (SMEEDS), and their parent drug delivery system, that is, emulsions, all come under a single closely related type of drug delivery system, in other words, they are oil-in-water or water-in-oil liquids, with other secondary additives in addition to the incorporated therapeutic agent.
https://www.tandfonline.com/doi/abs/10.1080/10837450.2019.1683749
Valsartan (VST) is a poorly water-soluble drug and a P-glycoprotein (P-gp) substrate. To enhance the dissolution and oral absorption of VST, a novel supersaturable self-microemulsifying drug delivery system (Su-SMEDDS) was formulated.Author: Yoon Tae Goo, Seh Hyon Song, Dong Woo Yeom, Bo Ram Chae, Ho Yub Yoon, Chang Hyun Kim, Sun Young Park...
https://link.springer.com/article/10.1007%2Fs13346-016-0342-7
Nov 03, 2016 · Valsartan, an angiotensin II receptor antagonist, is widely used to treat high blood pressure in the clinical setting. However, its poor water solubility results in the low oral bioavailability. The aim of this study was to improve dissolution rate and oral bioavailability by developing a self-nanoemulsifying drug delivery system. Saturation solubility of valsartan in various oils, surfactants ...Author: Zhenbao Li, Wenjuan Zhang, Yan Gao, Rongwu Xiang, Yan Liu, Mingming Hu, Mei Zhou, Xiaohong Liu, Yong...
https://www.dovepress.com/enhanced-oral-bioavailability-of-valsartan-using-a-polymer-based-super-peer-reviewed-article-IJN
Enhanced oral bioavailability of valsartan using a polymer-based supersaturable self-microemulsifying drug delivery system Dong Woo Yeom,1,* Bo Ram Chae,2,* Ho Yong Son,1 Jin Han Kim,1 Jun Soo Chae,1 Seh Hyon Song,2 Dongho Oh,2 Young Wook Choi1 1College of Pharmacy, Chung-Ang University, Seoul, 2Daewon Pharm. Co., Ltd, Seoul, Republic of Korea *These authors contributed …Author: Dong Woo Yeom, Bo Ram Chae, Ho Yong Son, Jin Han Kim, Jun Soo Chae, Seh Hyon Song, Dongho Oh, Young ...
https://www.researchgate.net/publication/336701859_Enhanced_oral_bioavailability_of_valsartan_in_rats_using_a_supersaturable_self-microemulsifying_drug_delivery_system_with_P-glycoprotein_inhibitors
A novel, supersaturable self-microemulsifying drug delivery system (S-SMEDDS) was successfully formulated to enhance the dissolution and oral absorption of valsartan (VST), a poorly water-soluble ...
https://www.hindawi.com/journals/bmri/2018/6763057/
The main purpose of this study was to investigate the potential of self-nanoemulsified drug delivery system (SNEDDS) to improve the oral bioavailability of tetrandrine (Tet). SNEDDS was developed by using rational blends of excipients with good solubilizing ability for Tet which was selected based on solubility studies. Further ternary phase diagram was constructed to determine the self ...Author: Chunxia Liu, Li Lv, Wei Guo, Lan Mo, Yaoxing Huang, Guocheng Li, Xingzhen Huang
https://www.pharmaexcipients.com/news/improved-dissolution-and-oral-bioavailability-of-valsartan/
To improve the dissolution and oral bioavailability of valsartan (VST), we previously formulated a supersaturable self-microemulsifying drug delivery system (SuSMED) composed of Capmul® MCM (oil), Tween® 80 (surfactant), Transcutol® P (cosurfactant), and Poloxamer 407 (precipitation inhibitor) but encountered a stability problem (Transcutol® P-induced weight loss in storage) after ...
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