Development Of Non Viral Vectors For Systemic Gene Delivery

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Development of non-viral vectors for systemic gene delivery

    https://www.sciencedirect.com/science/article/pii/S0168365901004941
    Jan 17, 2002 · However, non-viral delivery vehicles are still relatively inefficient. This review will focus on systemic gene delivery using new non-viral systems recently developed in our laboratory, including LPD1 (cationic liposome-entrapped, polycation-condensed DNA, type 1) …Author: Feng Liu, Leaf Huang

Development of non-viral vectors for systemic gene ...

    https://www.sciencedirect.com/science/article/abs/pii/S0168365901004941
    In this review, we summarize some of the recent advances in new non-viral delivery systems for systemic administration. Two types of gene delivery systems are described: (i) LPD1 (cationic liposome-entrapped, polycation-condensed DNA, type 1), and (ii) retention-time mediated naked DNA delivery.Author: Feng Liu, Leaf Huang

Development of Non-Viral Vectors for Systemic Gene Delivery

    https://www.researchgate.net/publication/11586313_Development_of_Non-Viral_Vectors_for_Systemic_Gene_Delivery
    Request PDF Development of Non-Viral Vectors for Systemic Gene Delivery One of the major challenges for gene therapy is systemic delivery of a nucleic acid directly into an affected tissue.

Viral and nonviral delivery systems for gene delivery

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
    Jul 06, 2012 · Although numerous viral and nonviral gene delivery systems have been developed in the last 3 decades, no delivery system has been designed that can be applied in gene therapy of all kinds of cell types in vitro and in vivo with no limitation and side effects.

Non Viral Vectors in Gene Therapy- An Overview

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347098/
    Jan 01, 2015 · The optimal vector and delivery system depends on the target cells and its characteristics, duration of expression and the size of the genetic material to be incorporated in the vector [3,4].The present vectors used for gene therapy are broadly classified as Viral vectors, Non-viral vectors and engineered vectors. The non-viral vectors are ...Author: Murali Ramamoorth, Aparna Narvekar

Development of non-viral vectors for systemic gene ...

    http://europepmc.org/abstract/MED/11772466
    Jan 01, 2002 · Development of non-viral vectors for systemic gene delivery. ... One of the major challenges for gene therapy is systemic delivery of a nucleic acid directly into an affected tissue. This requires developing a vehicle which is able to protect the nucleic acid from degradation, while delivering the gene of interest to the specific tissue and ...Author: Feng Liu, Leaf Huang

Non-Viral Delivery Systems in Gene Therapy IntechOpen

    https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
    Gene delivery systems include viral vectors and non-viral vectors. Viral vectors are the most effective, but their application is limited by their immunogenicity, oncogenicity and the small size of the DNA they can transport. Non-viral vectors are safer, of low cost, more reproducible and do not present DNA size limit.Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís

Gene therapy progress and prospects: non-viral gene ...

    https://www.nature.com/articles/3302838
    Sep 05, 2006 · Over the past decade, studies examining the mechanisms by which viral vectors are proficient at gene delivery have enabled us to further optimize …Author: Li Sd, Huang L

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