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https://www.sciencedirect.com/science/article/pii/S0168365901004941
Jan 17, 2002 · However, non-viral delivery vehicles are still relatively inefficient. This review will focus on systemic gene delivery using new non-viral systems recently developed in our laboratory, including LPD1 (cationic liposome-entrapped, polycation-condensed DNA, type 1) …Author: Feng Liu, Leaf Huang
https://www.sciencedirect.com/science/article/abs/pii/S0168365901004941
In this review, we summarize some of the recent advances in new non-viral delivery systems for systemic administration. Two types of gene delivery systems are described: (i) LPD1 (cationic liposome-entrapped, polycation-condensed DNA, type 1), and (ii) retention-time mediated naked DNA delivery.Author: Feng Liu, Leaf Huang
https://www.researchgate.net/publication/11586313_Development_of_Non-Viral_Vectors_for_Systemic_Gene_Delivery
Request PDF Development of Non-Viral Vectors for Systemic Gene Delivery One of the major challenges for gene therapy is systemic delivery of a nucleic acid directly into an affected tissue.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · Although numerous viral and nonviral gene delivery systems have been developed in the last 3 decades, no delivery system has been designed that can be applied in gene therapy of all kinds of cell types in vitro and in vivo with no limitation and side effects.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347098/
Jan 01, 2015 · The optimal vector and delivery system depends on the target cells and its characteristics, duration of expression and the size of the genetic material to be incorporated in the vector [3,4].The present vectors used for gene therapy are broadly classified as Viral vectors, Non-viral vectors and engineered vectors. The non-viral vectors are ...Author: Murali Ramamoorth, Aparna Narvekar
http://europepmc.org/abstract/MED/11772466
Jan 01, 2002 · Development of non-viral vectors for systemic gene delivery. ... One of the major challenges for gene therapy is systemic delivery of a nucleic acid directly into an affected tissue. This requires developing a vehicle which is able to protect the nucleic acid from degradation, while delivering the gene of interest to the specific tissue and ...Author: Feng Liu, Leaf Huang
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
Gene delivery systems include viral vectors and non-viral vectors. Viral vectors are the most effective, but their application is limited by their immunogenicity, oncogenicity and the small size of the DNA they can transport. Non-viral vectors are safer, of low cost, more reproducible and do not present DNA size limit.Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís
https://www.nature.com/articles/3302838
Sep 05, 2006 · Over the past decade, studies examining the mechanisms by which viral vectors are proficient at gene delivery have enabled us to further optimize …Author: Li Sd, Huang L
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