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https://www.sciencedirect.com/science/article/pii/S0168365901004941
Jan 17, 2002 · Vehicles for gene delivery, which have successfully demonstrated the delivery of exogenous genes in vivo, can be divided into two major groups: viral and non-viral vectors. Viral vectors include retrovirus, adenovirus, adeno-associated virus, herpes simplex virus and lentivirus.Author: Feng Liu, Leaf Huang
https://www.sciencedirect.com/science/article/abs/pii/S0168365901004941
In this review, we summarize some of the recent advances in new non-viral delivery systems for systemic administration. Two types of gene delivery systems are described: (i) LPD1 (cationic liposome-entrapped, polycation-condensed DNA, type 1), and (ii) retention-time mediated naked DNA delivery.Author: Feng Liu, Leaf Huang
https://www.researchgate.net/publication/11586313_Development_of_Non-Viral_Vectors_for_Systemic_Gene_Delivery
One of the major challenges for gene therapy is systemic delivery of a nucleic acid directly into an affected tissue. This requires developing a vehicle which is able to protect the nucleic acid from degradation, while delivering the gene of interest to the specific …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · There are different viral and nonviral vectors for gene delivery, but all gene therapy applications depend on the fact that the genetic material needs to be delivered across the cell membrane and ultimately to the cell nucleus.
https://www.nature.com/articles/3302838
Sep 05, 2006 · PEGylated nanoparticles with multiple components are the most promising non-viral vector for systemic delivery. Investigators in non-viral vector development have introduced a variety of strategies to overcome barriers for gene delivery. 1, 2, 3 These include (a) polynucleotide degradation in the extracellular space,...Author: Li Sd, Huang L
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347098/
Jan 01, 2015 · The optimal vector and delivery system depends on the target cells and its characteristics, duration of expression and the size of the genetic material to be incorporated in the vector [3,4].The present vectors used for gene therapy are broadly classified as Viral vectors, Non-viral vectors and engineered vectors. The non-viral vectors are Naked DNA, particle based and …Author: Murali Ramamoorth, Aparna Narvekar
https://www.nature.com/articles/nrg3763
Jul 15, 2014 · Synthetic delivery vectors have the potential to address many of the limitations of viral vectors, particularly with respect to safety. For systemic delivery of DNA, both lipid-based vectors …Author: Hao Yin, Rosemary L. Kanasty, Ahmed A. Eltoukhy, Arturo J. Vegas, Arturo J. Vegas, J. Robert Dorkin,...
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
Gene delivery systems include viral vectors and non-viral vectors. Viral vectors are the most effective, but their application is limited by their immunogenicity, oncogenicity and the small size of the DNA they can transport. Non-viral vectors are safer, of low cost, more reproducible and do not present DNA size limit.Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís
https://www.grandviewresearch.com/industry-analysis/viral-vector-manufacturing-market
The global viral vectors & plasmid DNA manufacturing market size was estimated at USD 368.3 million in 2019 and is projected to expand at a CAGR of 14.52% during the forecast period. Advent of advanced therapies including gene therapy that employs the use of various viral and non-viral vectors has paved a way for the treatment of several heritable and acquired diseases that previously lacked ...
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