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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465150/
Development and characterization of chronomodulated drug delivery system of captopril ... in most people. Conventional drug delivery system of captopril is inappropriate for the delivery of drug, as they cannot be administered just before the symptoms are worsened, because during this time the patients are asleep, bedtime dosing of captopril ...
https://www.researchgate.net/publication/232257562_Development_and_characterization_of_chronomodulated_drug_delivery_system_of_captopril
Development and characterization of chronomodulated drug delivery system of captopril Article (PDF Available) in International Journal of Pharmaceutical Investigation 1(4):227-33 · October 2011 ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381387/
To overcome the drawbacks of conventional drug delivery system for treatment of diseases with circadian variation, here hypertension, the chronomodulated drug delivery system was prepared by formulating capsule filled with immediate release granules (IRG) and …
https://www.researchgate.net/publication/229067218_Archana_PatilAsst_ProfessorRCCollege_of_Pharmacy_Belgaum_KarnatakaIndiaE-mail-_patil_archanyahoocoin
Development and characterization of chronomodulated drug delivery system of captopril with modified release dosage forms with zero order drug release theoretically leads to controlled and constant ...Author: Archana Patil
https://www.sciencedirect.com/science/article/pii/S1110093117300649
Pulsatile drug delivery system is time and site-specific drug delivery system, thereby providing special and temporal delivery and increasing patient compliance. Pulsatile drug delivery system is defined as the rapid and transient release of certain amount of molecules within a short time period immediately after a predetermined off-release ...Author: Komal Parmar, Almas Shaikh, Hitesh Dalvadi
https://en.wikipedia.org/wiki/Discovery_and_development_of_ACE_inhibitors
The discovery of an orally inactive peptide from snake venom established the important role of angiotensin converting enzyme (ACE) inhibitors in regulating blood pressure.This led to the development of Captopril, the first ACE inhibitor.When the adverse effects of Captopril became apparent new derivates were designed. Then after the discovery of two active sites of ACE: N-domain and C-domain ...
http://www.rguhs.ac.in/cdc/onlinecdc/uploads/04_P021_7170.doc
“DEVELOPMENT AND CHARACTERIZATION OF CHRONOMODULATED DRUG DELIVERY SYSTEM OF CAPTOPRIL FOR CARDIOVASCULAR DISEASES.” 6. BRIEF RESUME OF THE INTENDED WORK: 6.1 NEED FOR THE STUDY: With the advancement of technologies in the pharmaceutical field, drug delivery systems have drawn an increasing interest over the last few decades.
http://europepmc.org/articles/PMC2792514
A chronomodulated drug delivery system for salbutamol sulphate for the treatment of nocturnal asthma was successfully developed. The system was found to be satisfactory in terms of release of the drug after a lag time of 6 h. ... Development and characterization of chronomodulated drug delivery system of captopril. Patil AS, Dandagi PM ...
https://pubchem.ncbi.nlm.nih.gov/compound/captopril
Captopril is an angiotensin-converting enzyme (ACE) inhibitor used in the therapy of hypertension and heart failure. Captopril is associated with a low rate of transient serum aminotransferase elevations and has been linked to rare instances of acute liver injury.
https://issuu.com/iosrphr/docs/e0412203446
Jan 16, 2015 · Development and characterization of diltiazem hydrochloride pulsatile drug delivery system for chronomodulated therapy, Asian J Pharm Clin Res, 4(2), 2011, 168-173. C.
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