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https://www.sciencedirect.com/science/article/pii/S0022354915316245
A single-stranded DNA aptamer (APT) capable of targeting mucin 1 (MUC1) extracellular protein was modified to increase its drug delivery specificity toward MUC1 overexpressing cancer cell line, MCF7. The active targeting region of APT was truncated and variable repeats (one, two, or three) of this sequence were synthesized.Author: Lihan Tan, Lihan Tan, Koon Gee Neoh, En-Tang Kang, Woo-Seok Choe, Xiaodi Su
https://www.researchgate.net/publication/221881692_Designer_Tridentate_Mucin_1_Aptamer_for_Targeted_Drug_Delivery
Designer Tridentate Mucin 1 Aptamer for Targeted Drug Delivery. A single-stranded DNA aptamer (APT) capable of targeting mucin 1 (MUC1) extracellular protein was modified to increase its drug delivery specificity toward MUC1 overexpressing cancer cell line, MCF7.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033951/
Next, a photosensitizing agent chlorin e 6 was coupled to the 5’ amino group of the MUC-1 aptamers and targeted to cancer cells expressing the aberrant MUC-1 glycoforms. These conjugated MUC-1 aptamers produced cytotoxic singlet oxygen species upon photodynamic therapy (PDT) and displayed greater than 500 times enhanced cellular toxicity as compared to when chlorin e 6 was used as a free drug.Author: Partha Ray, Rebekah R. White
http://europepmc.org/abstract/MED/22383033
Jun 01, 2012 · A single-stranded DNA aptamer (APT) capable of targeting mucin 1 (MUC1) extracellular protein was modified to increase its drug delivery specificity toward MUC1 overexpressing cancer cell line, MCF7. The active targeting region of APT was truncated and variable repeats (one, two, or three) of this sequence were synthesized.Author: Lihan Tan, Lihan Tan, Koon Gee Neoh, En-Tang Kang, Woo-Seok Choe, Xiaodi Su
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284512/
Feb 22, 2012 · Due to these advantages, aptamers have been employed as novel targeting ligands in drug delivery systems against prostate cancer , , and leukemia . For the tumor marker of MUC1, Ferreira et al have developed several aptamers that could bind to the MUC1-positive tumor cells [15] .Author: Yan Hu, Jinhong Duan, Qimin Zhan, Fengdan Wang, Xin Lu, Xian-Da Yang
https://pubs.acs.org/doi/full/10.1021/bc0700741
Design and Synthesis of Mono- and Multimeric Targeted Radiopharmaceuticals Based on Novel Cyclen Ligands Coupled to Anti-MUC1 Aptamers for the Diagnostic Imaging and Targeted Radiotherapy of Cancer ... Aptamers as Drug Delivery Vehicles. ChemMedChem 2014, 9 ... Designer Tridentate Mucin 1 Aptamer for Targeted Drug Delivery. Journal of ...Author: K. Eszter Borbas, Catia S. M. Ferreira, Alan Perkins, James I. Bruce, Sotiris Missailidis
https://link.springer.com/article/10.1007%2Fs10930-016-9653-2
Mar 16, 2016 · Almost all of these aptamers are specific to clinically important peptide or protein targets. In addition, the application of protein specific aptamers in the design and development of targeted drug delivery systems and diagnostic biosensors is another intersting field of aptamer technology.Author: Maryam Tabarzad, Marzieh Jafari
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218254/
Aptamers as delivery agents. Aptamers can be designed as targeting ligands, particularly when generated by cell-based SELEX, and can differentiate diseased cells from healthy cells, thus enabling the selective delivery of therapeutic compounds to target cells (Table 1).Author: Weihong Tan, Weihong Tan, Hui Wang, Yan Chen, Yan Chen, Yan Chen, Xiaobing Zhang, Haizhen Zhu, Chaoy...
https://www.sciencedirect.com/science/article/pii/S0168365911001003
In this study, we report the design and delivery of a tumor-targeted, pH-responsive quantum dot-mucin1 aptamer-doxorubicin (QD-MUC1-DOX) conjugate for the chemotherapy of ovarian cancer. To achieve active cancer targeting, QD was conjugated with a DNA aptamer specific for mutated MUC1 mucin overexpressed in many cancer cells including ovarian carcinoma.Author: Ronak Savla, Oleh Taratula, Olga Garbuzenko, Tamara Minko
https://www.sciencedirect.com/science/article/pii/S0167779911001132
Aptamers can be designed as targeting ligands, particularly when generated by cell-based SELEX, and can differentiate diseased cells from healthy cells, thus enabling the selective delivery of therapeutic compounds to target cells (Table 1).Author: Weihong Tan, Weihong Tan, Hui Wang, Yan Chen, Yan Chen, Yan Chen, Xiaobing Zhang, Haizhen Zhu, Chaoy...
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