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https://www.nature.com/articles/nrd1775
Jul 01, 2005 · Design and development of polymers for gene delivery. ... The mechanisms of cytoplasmic polyplex transport need to be better characterized in order to facilitate design of improved polymeric vectors.Author: Daniel W. Pack, Allan S. Hoffman, Suzie Pun, Patrick S. Stayton
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417261/
Mar 12, 2019 · A new non-viral DNA delivery vectors of the terplex systems and polyethylene glycol-grafted poly(L-lysine) as polymeric gene carriers were also developed for gene delivery systems [102–105]. The clinical evaluations have currently made in the field of biomedical applications [ …Author: YK Sung, SW Kim
https://www.sciencedirect.com/science/article/pii/S016777991830060X
Gene delivery mediated by polymeric vectors is a multistage process. It involves multiple obstacles to overcome before the nucleic acid material can reach the target site (Figure 1, Key Figure).The target site here refers to the cytosol for RNA molecules and the nucleus for plasmids.Author: Wing-Fu Lai, Wing-Fu Lai, Wing-Tak Wong
http://www.nature.com/articles/doi:10.1038/nrd1775
Jul 01, 2005 · Design and development of polymers for gene delivery ... P. R. et al. Decreased binding to proteins and cells of polymeric gene delivery vectors surface modified with a multivalent hydrophilic ...
https://pubs.acs.org/doi/10.1021/bm300145q
This work demonstrates the relative importance of each of these tunable design criteria when creating a zwitterionic polymeric gene delivery vector and provides useful specific information regarding the design of bPEI-HA gene delivery vectors.Author: Clark J. Needham, Austin K. Williams, Sue Anne Chew, F. Kurtis Kasper, Antonios G. Mikos
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359729/
In this review, delivery systems including viral, non-polymeric, and polymeric vectors that have been used in glioblastoma multiforme (GBM) gene therapy are discussed. Additionally, advances in glioblastoma gene therapy using viral and non-polymeric vectors in clinical trials and emerging polymeric vectors for glioma gene therapy are discussed.Author: Breanne Caffery, Jeoung Soo Lee, Angela A. Alexander-Bryant
https://www.sciencedirect.com/science/article/pii/S0927776519305612
The field of gene therapy still attracts great interest due to its potential therapeutic effect towards the most deadly diseases, such as cancer. For cancer gene therapy to be feasible and viable in a clinical setting, the design and development of a suitable gene delivery system is imperative.Author: Ângela Sousa, Ana M. Almeida, Rúben Faria, Karidia Konate, Prisca Boisguerin, João A. Queiroz, Diana...
https://www.researchgate.net/publication/272080016_Defined_Polymeric_Materials_for_Gene_Delivery
Defined Polymeric Materials for Gene Delivery. ... transfection and further development of new gene vectors for biomedical applications. ... central importance in the design of efficient polymeric ...
https://biomaterialsres.biomedcentral.com/articles/10.1186/s40824-019-0156-z
Mar 12, 2019 · An important goal for the research of gene delivery system is to develop clinically relevant vectors that use to combat elusive diseases such as AIDS, cancer, Alzheimer, etc. DNA-based viral vectors for gene delivery systems utilize the viral vectors to deliver genetic materials to the host cells.Author: YK Sung, SW Kim
https://www.researchgate.net/publication/339911951_Polymeric_Nonviral_Gene_Delivery_Systems_for_Cancer_Immunotherapy
Unlike viral vectors with their undesired safety or immunogenicity concerns, biocompatible polymeric nonviral vectors as gene delivery systems are more promising in gene or cell therapy.
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