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https://phosphorex.com/benefits-of-depot-formulations.html
Jun 12, 2014 · BENEFITS OF DEPOT FORMULATIONS Microsphere-based long acting drug delivery products have been successfully used for over a decade. These depot formulations have distinct advantages, making them ideal for long-term sustained release applications.
https://www.sciencedirect.com/science/article/pii/S1359644618303945
Depot formulations, such as particulate delivery systems, semisolid formulations, and implants, can increase the contact time with the ocular tissue while sustaining the release of the contained drug . This overcomes the rapid clearance of administered drug via the periocular lymphatic system and reduces the dosing frequency.Author: Yosra Agban, Sachin S. Thakur, Odunayo O. Mugisho, Ilva D. Rupenthal
http://www.eurekaselect.com/74791/article/depot-based-drug-delivery-system-management-depression
Depot delivery offers the advantage of a very high loading, controlled release of drug for an extended period of time and reduces frequency of dosing. The increase in AUC and decrease in Cmax reflects that the depot formulations could reduce the toxic complications …Author: Urmila Pilaniya, Kapil Khatri, U. K. Patil
http://www.pharmtech.com/sustained-release-injectable-drug-delivery
Nov 01, 2010 · Another significant and unique advantage of parenteral injection is a long-term drug delivery by the formation of a depot or reservoir at the injection site after drug administration. As depicted in Table I, intravenous (IV) injection can be used for certain prolonged acting drugs due to the drugs' long half-lives in the body after IV administration.
https://www.delpor.com/delpors-device/comparison-to-depot-formulations/
Depot injections have been successfully introduced in certain markets and have illustrated the benefits of longer acting formulations. In 2003 the first atypical antipsychotic depot (2 week IM injection) was introduced to the schizophrenia market. The product showed very quickly the pharmacoeconomic benefits of a longer acting formulation by improving patient medication adherence and it
https://www.ema.europa.eu/en/documents/presentation/presentation-ema/ega-workshop-session-2-guideline-pharmacokinetic-clinical-evaluation-modified-release-dosage-forms_en.pdf
Intramuscular/subcutaneous depot formulations: A depot injection is usually a SC or IM product which releases its active compound continuously over a certain period of time. in vivo delivery is designed to continue for 1-2 months.
https://www.pharmatutor.org/articles/review-parenteral-controlled-drug-delivery-system
The Parenteral administration route is the most effective and common form of delivery for active drug substances with metabolic bio-availabilities drug for which the bio-availability in limited by high first pass metabolism effect of other physicochemical limitation and for drugs with a narrow therapeutic index.
https://www.slideshare.net/shraddhakumbhar25/depot-preparations-36922103
Jul 13, 2014 · TYPES OF DEPOT FORMULATION 1. Dissolution controlled depot formulation 2. Adsorption type depot formulation 3. Encapsulation type depot formulation 4. Esterification type depot formulation 7 8. Dissolution controlled depots RDS of drug absorption is dissolution of drug. • Approaches : Formation of salt or complexes with low aqueous solubility.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142089/
Sep 28, 2014 · A review of the field reveals several clinical and commercial success stories. Many sub-fields of drug delivery, i.e., transdermal drug delivery, depot injections, and oral drug delivery, have commercially successful products with annual sales exceeding a billion dollars.Author: Aaron C. Anselmo, Samir Mitragotri
https://en.wikipedia.org/wiki/Modified-release_dosage
Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release [ER, XR, XL] dosage) or to a specific target in the body (targeted-release dosage).
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