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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097927/
Patri et al. conjugated FA to G5 PAMAM dendrimer for the targeted delivery of methotrexate and observed receptor mediated drug delivery that demonstrated high specificity for KB cells overexpressing folate receptors and showed slower drug release.
https://www.sciencedirect.com/science/article/pii/B9780128145272000056
Pharmacodynamic studies showed the potential of targeted co-delivery of gene and drug with pH-triggered drug release at tumor site. The dose of DOX was reduced substantially with multifunctional dendrimers at which the side effects of DOX like weight loss and cardiotoxicity were negligible in …Author: Lakshmi Tunki, Hitesh Kulhari, Ramakrishna Sistla, Deep Pooja
https://pubs.rsc.org/en/content/articlelanding/2013/tb/c3tb20724b
This review reports some recent advances on the use of dendrimers as a versatile platform for targeted drug delivery applications. The unique 3-dimensional architectures and macromolecular characteristics afford dendrimers with ideal drug delivery ability through encapsulating drugs in their interior or covalently conjugating drugs on their surfaces.Author: Jingyi Zhu, Xiangyang Shi
https://www.pharmatutor.org/articles/dendrimers-novel-drug-delivery-overview
Dendrimers are being used as drug delivery systems for various drugs like anticancer drugs (methotrexate), drug for prevention of HIV, enhancing bioavailability of pilocarpine for ocular drug delivery. Dendrimers help in achieving increased bioavailability, sustained, controlled as well as targeted release of drug.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017392/
Apr 18, 2018 · Dendrimer nanotechnology due to its multifunctional ability has the potential to create next generation drug delivery platforms. The future of dendrimers would be to exploit their multifunctional capabilities and engineerable platforms. The idea that sprouted through the ‘tree branches’ has now taken ‘root’ in drug delivery.Author: Abhay Singh Chauhan
https://www.sciencedirect.com/science/article/pii/S1359644616304469
Targeted drug delivery particularly to cancer cells could be achieved with multifunctional nanocarriers . Dendrimers are defined as synthetic, extremely branched, globular, monodispersed with spatial arrangement and nanometric macromolecules mainly used as nanocarriers for targeted drug delivery and solubilization of poorly water-soluble drugs.Author: Prashant Kesharwani, Avinash Gothwal, Arun K. Iyer, Arun K. Iyer, Keerti Jain, Manish K. Chourasia, ...
https://ashpublications.org/hematology/article/2009/1/708/19890/Dendrimer-based-nanoparticles-for-cancer-therapy
Jan 01, 2009 · Mice on right dosed with dendrimer-transported folate-targeted methotrexate exhibit no adverse effects from the chemotherapy. Drug-induced necrosis of the tumor on the flank of the mouse in the upper right corner.Author: James R. Baker
https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.0c00075
Monoclonal Antibody 2C5-Modified Mixed Dendrimer Micelles for Tumor-Targeted Codelivery of Chemotherapeutics and siRNA Molecular Pharmaceutics Targeted delivery of chemotherapeutics to tumors has the potential to reach a high dose at the tumor while minimizing systemic exposure.
https://pubs.acs.org/doi/10.1021/bm201566g
Biophysical Characterization of a Riboflavin-Conjugated Dendrimer Platform for Targeted Drug Delivery Biomacromolecules The present study describes the biophysical characterization of generation-five poly(amidoamine) (PAMAM) dendrimers conjugated with riboflavin (RF) as a cancer-targeting platform.Author: Amanda B. Witte, Christine M. Timmer, Jeremy J. Gam, Seok Ki Choi, Mark M. Banaszak Holl, Bradford G...
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