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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816686/
Dendrimers as siRNA Delivery Vectors Dendrimers are among the most widely used cationic polymers for nucleic acid delivery. However, as was said earlier, delivery of siRNA in …Author: Swati Biswas, Vladimir P. Torchilin
https://www.ncbi.nlm.nih.gov/pubmed/26472447
Small interfering RNA (SiRNA) delivery remains a major challenge in RNAi-based therapy. Dendrimers are emerging as appealing nonviral vectors for SiRNA delivery thanks to their well-defined architecture and their unique cooperativity and multivalency confined within a nanostructure.Author: Xiaoxuan Liu, Ling Peng
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830781/
Both nontargeted and targeted dendrimer/siRNA complexes formed compact nanoparticles, exhibited low cytotoxicity, and efficiently penetrated cancer cells in vitro. However, only the targeted dendrimer-siRNA complex was able to substantially decrease the expression of a targeted BCL2 gene . In 2011 this group developed a triblock poly(amidoamine)-poly(ethylene glycol)-poly-L-lysine (PAMAM-PEG-PLL) carrier for siRNA delivery.Author: Jiangyu Wu, Weizhe Huang, Ziying He
https://www.mdpi.com/1424-8247/6/2/161/htm
The dendrimer-siRNA-SPION particles were stabilized with PEG, the distal end of which was coupled with the tumor homing peptide, LHRH. This multi-functional system delivered siRNA specifically to the cancer cells and allowed monitoring of the therapeutic outcome using simultaneous imaging techniques.Author: Swati Biswas, Vladimir P. Torchilin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096033/
May 27, 2016 · However, virus‐like particles are prone to be cleared by virus‐specific antibodies 6 and lipid‐based siRNA delivery systems are rapidly removed by the liver and spleen. 7 Polymers and dendrimers used for siRNA delivery often exhibit toxicity and nonspecific cell uptake because they are often highly positively charged. 8 Such drawbacks of transfection agents are reasons that RNA …Author: Martin G. Nussbaumer, Jason T. Duskey, Martin Rother, Kasper Renggli, Mohamed Chami, Nico Bruns, Nic...
https://pubs.acs.org/doi/pdfplus/10.1021/jacs.8b10021
dendrimer-based siRNA delivery system with the dual targeting RGDK warhead constitutes a powerful approach to achieve effective and specific tumor targeting for more efficient siRNA delivery and potent gene silencing. This approach can be further developed for RNAi-based personalized medicine in fi ghting cancer. RESULTS AND DISCUSSION
https://www.sciencedirect.com/science/article/pii/S0378517318303557
Fourthly, this review also described the advantages of PAMAM dendrimer-based drug and pDNA/siRNA delivery using PAMAM dendrimers in a hybrid system or PAMAM linked/loaded in multistage nanoparticles. Overall, PAMAM-based drug and gene delivery systems will result in even more effective nanocarriers for cancer therapy.Author: Jun Li, Huamin Liang, Jing Liu, Ziyuan Wang
https://www.sciencedirect.com/science/article/pii/S1369702115002023
To achieve siRNA delivery to a transgenic murine model of glioblastoma, magnetic nanoparticles bearing polyvalent G4 dendrimers with a cystamine core (called dendriworms) were developed . Authors reported that no significant in vitro toxicity in HeLa cells was seen at different concentrations of dendriworm or siRNA. It was also reported that siRNA and dendriworm doses strongly influenced …Author: Prashant Kesharwani, Sanjeev Banerjee, Umesh Gupta, Mohd Cairul Iqbal Mohd Amin, Subhash Padhye, Faz...
https://www.europepmc.org/articles/PMC3047462/
PAMAM-RGD conjugates enhance siRNA delivery through a multicellular spheroid model of malignant glioma. Find the latest peer-reviewed research articles and preprints on Coronavirus here. Feedback Complete survey. Sign in or create an account. https ...
https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.0c00075
Targeted delivery of chemotherapeutics to tumors has the potential to reach a high dose at the tumor while minimizing systemic exposure. Incorporation of antibody within a micellar platform represents a drug delivery system for tumor-targeted delivery of antitumor agents. Such modified immunomicelles can result in an increased accumulation of antitumor agents and enhanced cytotoxicity toward ...
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