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https://www.sciencedirect.com/science/article/pii/S0168365903002001
The transdermal delivery of aqueous formulations of indomethacin, a model drug, with different concentrations of three types of dendrimer showed a linear increase in flux with increasing concentration of each of the dendrimers. This result was in contrast to phase solubility studies, where Higuchi’s A N profile was observed.Author: Abhay S Chauhan, S Sridevi, Kishore B Chalasani, Akhlesh K Jain, Sanjay K Jain, N.K Jain, Prakash V ...
https://www.researchgate.net/publication/10644382_Dendrimer-mediated_transdermal_delivery_Enhanced_bioavailability_of_indomethacin
Request PDF Dendrimer-mediated transdermal delivery: Enhanced bioavailability of indomethacin The transdermal delivery of aqueous formulations of indomethacin, a model drug, with different ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017392/
Apr 18, 2018 · 2.3. Dendrimer-Mediated Transdermal Delivery . The transdermal delivery of indomethacin formulations with different dendrimers was studied and transdermal permeation potential was evaluated (Figure 6) . The effect of concentrations of dendrimers was observed and it showed a linear increase in flux with an increasing concentration of each of the ...Author: Abhay Singh Chauhan
https://fcd.mcw.edu/?module=search&func=showPublication&id=712046
Dendrimer-mediated transdermal delivery: enhanced bioavailability of indomethacin. J Control Release 2003 Jul 31;90(3):335-43 Date 07/26/2003 Pubmed ID 12880700 DOI 10.1016/s0168-3659(03)00200-1 Abstract. The transdermal delivery of aqueous formulations of indomethacin, a model drug, with different concentrations of three types of dendrimer ...
https://www.researchgate.net/publication/11294341_Transdermal_Delivery_of_Indomethacin_by_Iontophoresis
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https://www.sciencedirect.com/science/article/pii/S0022354916322092
The transdermal bioavailability of NSAIDs was also enhanced by dendrimers, as demonstrated by both pharmacodynamic and pharmacokinetic studies. Although dendrimer-mediated drug-delivery is in its infancy, it offers a number of attractive features.Author: Cheng Yiyun, Man Na, Xu Tongwen, Fu Rongqiang, Wang Xueyuan, Wang Xiaomin, Wen Longping
https://en.wikipedia.org/wiki/PAMAM
Poly(amidoamine), or PAMAM, is a class of dendrimer which is made of repetitively branched subunits of amide and amine functionality.PAMAM dendrimers, sometimes referred to by the trade name Starburst, have been extensively studied since their synthesis in 1985, and represent the most well-characterized dendrimer family as well as the first to be commercialized.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517524/
The purpose of the present study was to develop a novel transdermal drug-delivery system comprising a polyamidoamine dendrimer coupled with sonophoresis to enhance the permeation of diclofenac (DF) through the skin. The novel transdermal drug-delivery system was developed by using a statistical Plackett–Burman design.Author: Bin Huang, Wei-Jiang Dong, Gao-Yi Yang, Wei Wang, Cong-Hua Ji, Fei-Ni Zhou
https://www.ijpsonline.com/articles/dendrimeric-nanoarchitectures-mediated-transdermal-and-oral-delivery-of-bioactives.html
Jun 11, 2007 · Skin intrinsic barrier furnish a foremost confront in transdermal drug deliverance. Stratum corneum, the outermost cover of the skin, offers principal hurdle for diffusion of hydrophilic ionizable bioactives. Novel epoch go forward in transdermal drug delivery system is the dendrimer mediated transdermal delivery of bioactives.Author: V Gajbhiye, P Vijayaraj Kumar, A Sharma, A Agarwal, A Asthana, NK Jain
https://www.dovepress.com/dendrimer-coupled-sonophoresis-mediated-transdermal-drug-delivery-syst-peer-reviewed-fulltext-article-DDDT
In the case of run 3, the cumulative drug that permeated through the skin was 935.21 µg/cm2. It was concluded that dendrimer-coupled sonophoresis-mediated transdermal drug delivery system has the potential to enhance the permeation of DF through the skin. Keywords: sonophoresis, ultrasound, polyamidoamine, permeation enhancers, stratum corneum
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