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https://www.ncbi.nlm.nih.gov/pubmed/11998447
The drug 5-fluorouracil (5-FU) was entrapped in dendrimer grafts. The effects of various solvents (ethanol, dichloromethane, tetrahydrofuran), pH and ionic strength on solubilization of 5-FU were determined. Phospholipid was further coated on the dendrimer grafts.Author: Tripathi Pk, Khopade Aj, Nagaich S, Shrivastava S, Jain S, Jain Nk
https://www.researchgate.net/publication/11373180_Dendrimer_grafts_for_delivery_of_5-flurouracil
Request PDF Dendrimer grafts for delivery of 5-flurouracil Polyamidoamine (PAMAM) dendrimers were prepared by linking methyl methacrylate and ethylenediamine successively on an amine core ...
https://www.sciencedirect.com/science/article/pii/B9780128145272000068
Recently Dendrimer that is a globular, nanosized (1–100 nm) synthetic macromolecule has been explored as drug delivery vehicle for anticancer drugs. Dendrimer term originates from ‘dendron’ meaning a tree in Greek and in arborols the Latin word ‘arbor’ also meaning a tree.Author: Pushpendra Kumar Tripathi, Shalini Tripathi
https://www.tandfonline.com/doi/abs/10.1080/1061186X.2016.1207649
Aug 03, 2017 · Herein, a unique nanomicelle based on amphiphilic dendrimer (AmD) consisting of a hydrophilic polyamidoamine dendritic shell and a hydrophobic polylactide core is developed for effectively loading and shuttling 5-fluorouracil (5-Fu) and doxorubicin (Dox).Author: Rui Han, Yuan Sun, Chen Kang, Huijing Sun, Wenguang Wei
https://www.pharmatutor.org/articles/dendrimers-carrier-for-oral-drug-delivery-system
Exceptional feature of a dendrimer includes a high degree of structural symmetry, a density gradient displaying an intra-molecular minimum value and a well defined number of terminal groups. Dendrimers are normally used as carriers for drug delivery especially for oral, ocular and transdermal delivery.
https://www.sciencedirect.com/science/article/pii/S0378517308004274
Amine terminated generation 4 (G4-NH 2) PAMAM dendrimer is used in this study and has been widely used for drug delivery studies (Kitchens et al., 2005). 5-Fluorouracil (5FU) is used as a model hydrophilic drug (log P = −0.89) and the drug is poorly permeable through skin (Cornwell and Barry, 1993).Author: Venkata Vamsi K. Venuganti, Omathanu P. Perumal
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245407/
This acetylated dendrimers were then reacted with 1-bromoacetyl-5-fluorouracil to form a 5-FU dendrimer carrier that reduced the drug toxicity due to a slow release (≈ 10 days). Bhadra et al . [ 77 ] focussed their investigation in the design of PEGylated polyamidoamine (PAMAM) dendrimers.Author: José L. Arias
https://pubs.acs.org/doi/10.1021/acsami.7b00221
In this work, we describe synthesis and characterization of novel in situ-forming polyamidoamine (PAMAM) dendrimer hydrogels (DHs) with tunable properties prepared via highly efficient aza-Michael addition reaction. PAMAM dendrimer G5 was chosen as the underlying core and functionalized with various degrees of acetylation using acetic anhydride. The nucleophilic amines on the dendrimer …Author: Juan Wang, Hongliang He, Remy C. Cooper, Hu Yang
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