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https://www.sciencedirect.com/science/article/pii/S1359644616303373
Zhang et al. synthesized and characterized an enzyme-responsive mPEGylated peptide dendrimer–GFLG–doxorubicin conjugate (dendrimer–GFLG–DOX) as a nanoscale drug delivery vehicle for the effective management of ovarian cancer therapy via a two-step highly efficient copper-catalyzed alkyne–azide click cycloaddition (CuAAC) reaction. The above formulation was …Author: Ashok Kumar Sharma, Avinash Gothwal, Prashant Kesharwani, Hashem Alsaab, Arun K. Iyer, Arun K. Iyer,...
https://www.pharmatutor.org/articles/denrimers-novel-therapy-for-cancer
To begin the discussion of properties that make dendrimers attractive vehicles for cancer treatment, we revisit the concept that encapsulation or covalent linkage of small molecule drug candidates to a dendrimer enhances the pharmacological properties of the drug. In cancer chemotherapy, these desirable size-based features are reinforced by the enhanced permeability and retention (EPR) effect that improves the delivery …
https://onlinelibrary.wiley.com/doi/abs/10.1002/9783527610419.ntls0071
Sep 15, 2007 · Dendrimers in Cancer Diagnosis and Treatment Dendrimers have Attractive Properties for Cancer Treatment. Dendrimer‐sized Particles Passively Accumulate at the Sites of Tumors. Multifunctional Dendrimers can Selectively Target Biomarkers found on Cancer Cells Methods for Targeting Specific Biomarkers of Cancer.Author: Srinivasa‐Gopalan Sampathkumar, Kevin J. Yarema
https://timesofindia.indiatimes.com/blogs/scientifically-trended/are-dendrimers-the-new-age-anti-cancer-drug-delivery-agents/
Oct 25, 2018 · Among these, dendrimers have evolved to be one of the most favourable agents for the researchers and the technologists in context to the gene therapy and anti-cancer properties due to its highly equipped drug loading efficiency, predictable release pathway,...Author: Sayan Basak
https://www.sciencedirect.com/science/article/pii/S2352940718301641
Targeted drug delivery using nanomaterials such as PAMAM dendrimer bearing ligands has several advantages: (a) it can protect normal cells from cytotoxic agents; (b) it can reduce the dose-dependent side-effects of drugs; (c) it can overcome drug resistance of cancer cells [81].Author: Fereydoon Abedi-Gaballu, Fereydoon Abedi-Gaballu, Gholamreza Dehghan, Maryam Ghaffari, Maryam Ghaffa...
https://www.sciencedirect.com/science/article/pii/B9780128157206000071
The investigation suggested that PEGylated dendrimers might be a potential tool for pulmonary drug delivery to achieve controlled and sustained exposure of chemotherapeutic drugs in lung cancer with improved efficacy and safety .Author: Bapi Gorain, Hira Choudhury, Manisha Pandey, Anroop B. Nair, Mohd Cairul Iqbal Mohd Amin, Nagashekha...
https://ashpublications.org/hematology/article/2009/1/708/19890/Dendrimer-based-nanoparticles-for-cancer-therapy
Jan 01, 2009 · Since the affinity of folate conjugates for the cell surface folate receptors is high (K D ~ 10 −10 M), the folic acid modification of dendrimers allows the specific delivery of diagnostic and therapeutic agents to cancer cells. Thus, dendrimer folic acid conjugates linked to either a single drug molecule or assembly of molecules can bind to and enter receptor-expressing tumor cells via folate …Author: James R. Baker
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074873/
May 21, 2014 · Requirements for dendrimer-based, cancer-targeted drug delivery. (A) Dendrimers with multiple surface functional groups can be directed to cancer cells by tumor-targeting entities that include folate or antibodies specific for tumor-associated antigens...Author: Elham Abbasi, Sedigheh Fekri Aval, Abolfazl Akbarzadeh, Morteza Milani, Hamid Tayefi Nasrabadi, Sang...
https://www.nature.com/articles/s41392-017-0004-3
Mar 16, 2018 · Alginate-PAMAM dendrimer-based hybrid nanogels have been developed for drug delivery to cancer cells, and they showed pH-dependent release behavior in a sustained way 131. Nanocarriers have been ...Author: Sudipta Senapati, Arun Kumar Mahanta, Sunil Kumar, Pralay Maiti
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097927/
Patri et al. conjugated FA to G5 PAMAM dendrimer for the targeted delivery of methotrexate and observed receptor mediated drug delivery that demonstrated high specificity for KB cells overexpressing folate receptors and showed slower drug release.
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