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https://www.sciencedirect.com/science/article/pii/S2352940718301641
3.2.1. DNA delivery using PAMAM dendrimer. PAMAM dendrimers possess amine groups on their surface and their interior. The surface amine groups have essential roles in binding and compacting the negatively charged DNA into overall neutrally-charged nanoparticles, thus increasing the cellular uptake of DNA and other nucleic acids . However, the ...Author: Fereydoon Abedi-Gaballu, Fereydoon Abedi-Gaballu, Gholamreza Dehghan, Maryam Ghaffari, Maryam Ghaffa...
https://www.ncbi.nlm.nih.gov/pubmed/29787895
Jul 30, 2018 · Poly (amidoamine) (PAMAM) dendrimers are well-defined, highly branched macromolecules with numerous active amine groups on the surface. Because of their unique properties, PAMAM dendrimers have steadily grown in popularity in drug delivery, gene therapy, medical imaging and diagnostic application.Author: Jun Li, Huamin Liang, Jing Liu, Ziyuan Wang
https://www.sciencedirect.com/science/article/pii/S0169409X05001936
Depending on the ratio of DNA and dendrimer various supramolecular aggregates of DNA and dendrimers exist. The observation of distinctive phases of high and low solubility aggregates at low, medium, and high ratios of PAMAM dendrimer to DNA (expressed as surface groups to DNA base pairs) can be explained as illustrated.Author: Christine Dufès, Ijeoma F. Uchegbu, Andreas G. Schätzlein
https://pubs.acs.org/doi/abs/10.1021/bm501731f
DNA dendrimers consisting of several branched DNA units connected to each other using DNA ligase were quite effective for the delivery of immunostimulatory CpG DNA to immune cells. Therapeutic application of such DNA dendrimers, however, is hampered by the use of the ligase. Here, we report that self-assembling DNA dendrimers with high immunostimulatory potency can be prepared without DNA ...Author: Kohta Mohri, Eri Kusuki, Shozo Ohtsuki, Natsuki Takahashi, Masayuki Endo, Kumi Hidaka, Hiroshi Sugiy...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074873/
May 21, 2014 · To maintain the activity of DNA during dehydration, the dendrimer/DNA complexes were encapsulated in a water soluble polymer and then deposited on or sandwiched in functional polymer films with a fast degradation rate to mediate gene transfection.Author: Elham Abbasi, Sedigheh Fekri Aval, Abolfazl Akbarzadeh, Morteza Milani, Hamid Tayefi Nasrabadi, Sang...
https://pubs.acs.org/doi/10.1021/ma0106346
Mar 27, 2002 · We demonstrate a simple and successful synthetic approach to devise a highly efficient DNA delivery system with low cytotoxicity and low cost. Polyamidoamine (PAMAM) dendrimer is a highly efficient DNA delivery agent, when compared to other chemical transfection reagents. Partially degraded, high-generation dendrimers offer even higher efficiency, presumably due to enhanced …Author: Dan Luo, Kraig Haverstick, Nadya Belcheva, Ernest Han, W. Mark Saltzman
https://www.nature.com/articles/s41598-018-27400-6
Jun 20, 2018 · The conjugation of M-PEG2K, M-PEG5K and M-PEG10K to DAB dendrimers resulted in a decrease in the zeta potential of all dendriplexes at all the tested dendrimer…Author: Sukrut Somani, Partha Laskar, Najla Altwaijry, Paphitchaya Kewcharoenvong, Craig Irving, Gillian Rob...
https://www.unmc.edu/pharmacy/faculty/pharmaceutical-sciences/docs/v6.pdf
Structure/Function Relationships of Polyamidoamine/DNA Dendrimers as Gene Delivery Vehicles CHAD S. BRAUN, 1JOSEPH A. VETRO, DONALD A. TOMALIA,2 GARY S. KOE,3 JANET G. KOE,3 C. RUSSELL MIDDAUGH1 1Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Ave., Lawrence, Kansas 66047 2Dendritic Nanotechnologies, Mt. Pleasant, Michigan 48858
https://en.wikipedia.org/wiki/Poly(amidoamine)
Poly(amidoamine), or PAMAM, is a class of dendrimer which is made of repetitively branched subunits of amide and amine functionality.PAMAM dendrimers, sometimes referred to by the trade name Starburst, have been extensively studied since their synthesis in 1985, and represent the most well-characterized dendrimer family as well as the first to be commercialized.
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