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Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347861/
    Sep 01, 2011 · In past two decades poly lactic-co-glycolic acid (PLGA) has been among the most attractive polymeric candidates used to fabricate devices for drug delivery and tissue engineering applications.PLGA is biocompatible and biodegradable, exhibits a wide range of erosion times, has tunable mechanical properties and most importantly, is a FDA approved polymer.Author: Hirenkumar K. Makadia, Steven J. Siegel

PLGA - an overview ScienceDirect Topics

    https://www.sciencedirect.com/topics/neuroscience/plga
    PLGA is a biodegradable copolymer ester of two α-hydroxyacids (lactic and glycolic acids) and has been approved by the FDA for antigen delivery. PLGA nanocarriers undergo degradation by bulk erosion mechanism, thereby eliciting sustained release of antigen from the matrix.

Cellular delivery of PEGylated PLGA nanoparticles

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319145/
    PLGA is non-toxic and already approved by the FDA for human use. Several investigators have already reported the synthesis and cytotoxicity of PEGylated PLGA nanoparticles. Based on cell cytotoxicity assay these PEGylated PLGA particles are as safe as PLGA and …Author: Sarala Pamujula, Sidhartha Hazari, Gevoni Bolden, Richard A. Graves, Dakshinamurthy Devanga Chinta, ...

Delivery of FK506-loaded PLGA nanoparticles prolongs ...

    https://www.sciencedirect.com/science/article/pii/S0378517319309962
    The in vitro release of FK506 from PLGA-FK506-NPs was investigated by a dialysis method at preset times. As shown in Fig. 3, free FK506 solution exhibited a rapid release behavior; more than 90% of FK506 was released within 16 h, and almost 100% was released within 24 h.In contrast, the PLGA-FK506-NPs exhibited a nearly linear FK506 release profile; approximately 22.68 ± 2.65% of the FK506 ...Author: Cheng Deng, Yihan Chen, Li Zhang, Ya Wu, Huiling Li, Yu Wu, Bin Wang, Zhenxing Sun, Yuman Li, Qing L...

(PDF) PLGA: A unique polymer for drug delivery

    https://www.researchgate.net/publication/270765946_PLGA_A_unique_polymer_for_drug_delivery
    Biodegradable polymers have played an important role in the delivery of drugs in a controlled and targeted manner. Polylactic-co-glycolic acid (PLGA) is one of the extensively researched synthetic ...

Degradex® Microspheres and Nanoparticles for Drug Delivery ...

    https://www.sigmaaldrich.com/technical-documents/articles/technology-spotlights/degradex-microspheres-nanoparticles.html
    Degradex ® PLGA Particles. Degradex ® PLGA microspheres and nanoparticles are polymeric particles in the size range of nanometers to microns. Both plain and fluorescently dyed particles are available. Plain PLGA microspheres and nanoparticles can be used in drug delivery research and formulation as control agents or can be used to test system compatibility before loading an API into the carrier.

Polymer degradation and drug delivery in PLGA‐based drug ...

    http://kinampark.com/PLGARef/files/Xu%202016%2C%20Polymer%20degradation%20and%20drug%20delivery%20in%20PLGA-based%20drug%E2%80%93polymer%20Applications-%20A%20review%20of%20experiments%20and%20theories.pdf
    Review Article Polymer degradation and drug delivery in PLGA-based drug–polymer applications: A review of experiments and theories Yihan Xu,1 Chang-Soo Kim,1* David M. Saylor,2 Donghun Koo3* 1Materials Science and Engineering Department, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, 53211 2Division of Biology, Chemistry, and Materials Science, Center for Devices and …

Solubility enhancement using PEG-polyester diblock ...

    https://www.sigmaaldrich.com/technical-documents/articles/materials-science/plga-drug-delivery.html
    Solubility enhancement of hydrophobic drugs via drug-loaded micelles using biodegradable PEG- polyester diblock copolymers The requirement for large quantities of saline to dissolve such materials limits their clinical use, and one solution for this problem that has recently generated interest is the formation of drug-loaded micelles.

A mechanistic model for drug release in PLGA biodegradable ...

    http://web.mit.edu/braatzgroup/a_mechanistic_model_for_drug_release_in_plga_diodegradable_stent_coatings_coupled_with_polymer_degradation_and_erosion.pdf
    drug delivery. Modeling the PLGA degradation and erosion is a prereq-uisite for drug release modeling, and mechanistic approaches are most commonly employed, as described in papers on PLGA-based drug delivery systems such as micro-spheres.17,18 A simple and convenient approach for describ-ing degradation, or the MW change, uses first-order

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