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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698461/
RNA interference (RNAi) is caused by small (21 − 23 bases long) single-stranded RNA molecules (small-interfering RNA; siRNA), which trigger silencing of target genes in a sequence-specific manner [1,2]. The siRNA's sequence is ‘anti-sense’ (or complementary) to a specific stretch of the messenger RNA (mRNA) transcribed by the target gene.Author: Saroj P Mathupala
https://www.ncbi.nlm.nih.gov/pubmed/29422412
Small interfering RNA (siRNA)-based gene silencing technology has demonstrated significant potential for treating brain-associated diseases. However, effective and safe systemic delivery of siRNA into the brain remains challenging because of biological barriers such as enzymatic degradation, short circulation lifetime, the blood-brain barrier ...Author: Meng Zheng, Wei Tao, Yan Zou, Omid C. Farokhzad, Bingyang Shi
https://www.nature.com/articles/nature05901
Jun 17, 2007 · Attachment of a piece of viral protein to a small RNA achieves transfer of the RNA into neuronal cells in cell culture. This was also able to deliver an antiviral siRNA specifically into the ...Author: Priti Kumar, Haoquan Wu, Jodi L. McBride, Kyeong-Eun Jung, Moon Hee Kim, Beverly L. Davidson, Sang K...
https://www.researchgate.net/publication/24427016_Delivery_of_small-interfering_RNA_siRNA_to_the_brain
Delivery of small-interfering RNA (siRNA) to the brain Article · Literature Review (PDF Available) in Expert Opinion on Therapeutic Patents 19(2):137-40 · March 2009 with 54 Reads
https://www.sciencedirect.com/science/article/pii/S0142961213009848
To improve the efficiency of small interfering RNA (siRNA) delivery to the brain, we developed a nose-to-brain delivery system combined with cell-penetrating peptide (CPP) modified nano-micelles comprising polyethylene glycol–polycaprolactone (PEG–PCL) copolymers conjugated with the CPP, Tat (MPEG–PCL–Tat).Author: T. Kanazawa, F. Akiyama, S. Kakizaki, Y. Takashima, Y. Seta
https://www.nature.com/articles/nbt.1807
Mar 20, 2011 · Delivery of therapeutic siRNA to specific tissues is a major challenge. Alvarez-Erviti et al. show that exosomes—small vesicles that are naturally secreted by many animal cells—can be ...Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
https://www.researchgate.net/publication/6263796_Transvascular_delivery_of_small_interfering_RNA_to_the_central_nervous_system
(RVG) enables the transvas cular delivery of small interfering RNA (siRNA) to the brain. This 29-amino-acid peptide specifically bind s to the acetylcholine receptor expressed by neuronal cells.
https://ohsu.pure.elsevier.com/en/publications/transvascular-delivery-of-small-interfering-rna-to-the-central-ne-2
Jul 07, 2007 · A major impediment in the treatment of neurological diseases is the presence of the blood-brain barrier, which precludes the entry of therapeutic molecules from blood to brain. Here we show that a short peptide derived from rabies virus glycoprotein (RVG) enables the transvascular delivery of small interfering RNA (siRNA) to the brain.Author: Priti Kumar, Haoquan Wu, Jodi L. McBride, Kyeong-Eun Jung, Moon Hee Kim, Beverly L. Davidson, Sang K...
http://www.signaling-gateway.org/update/updates/200708/nrn2205.html
A new technique enables the targeted delivery of small interfering RNA (siRNA) molecules across the blood brain barrier to the central nervous system, permitting gene-by-gene analysis of brain function and validation of therapeutic targets.
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