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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857543/
Lipid drug delivery is another area that has shown great promise for use with therapeutic proteins. 116 – 118 As a whole, lipid delivery encompasses liposomes, solid lipid nanoparticles, oily suspensions, submicron lipid emulsions, lipid implants, lipid microbubbles, inverse lipid micelles, cochliar liposomes, and lipid microtubules, and lipid microcylinders (Figure 3A). 119 The most …Author: Dipak S. Pisal, Matthew P. Kosloski, Sathy V. Balu-Iyer
https://pubs.acs.org/doi/10.1021/acs.bioconjchem.9b00096
Protein/peptide delivery is likewise an important area, ably covered by Yin. In my mind, intracellular biologics is the next “big deal” in therapeutics, as can be witnessed by the diversity of researchers and start-up companies focusing their efforts in this field.Author: Theresa M. Reineke, Ronald T. Raines, Vincent M. Rotello
https://pubs.acs.org/doi/10.1021/jacs.8b10947
Imaging studies demonstrate that the polymer–protein conjugates are successfully delivered into the cytosol of various cancer cell lines, likely through a membrane fusion mechanism. When conjugated to the delivery polymers, the activity of modified RNase A was retained and notably promoted cytotoxicity in cancer cells upon delivery to the cytosol.Author: Rapeepat Sangsuwan, Phum Tachachartvanich, Matthew B. Francis
https://www.nature.com/articles/nbt.3081
Oct 30, 2014 · Efficient intracellular delivery of proteins is needed to fully realize the potential of protein therapeutics. Current methods of protein delivery commonly suffer from low tolerance for serum, poor endosomal escape and limited in vivo efficacy.Author: John A. Zuris, John A. Zuris, David B. Thompson, David B. Thompson, Yilai Shu, John P. Guilinger, Jo...
https://www.cell.com/cell/fulltext/S0092-8674(15)00315-3
Apr 23, 2015 · Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo.Author: Diego S. D’Astolfo, Romina J. Pagliero, Anita Pras, Wouter R. Karthaus, Hans Clevers, Vikram Prasad,...
https://www.nature.com/articles/s41551-019-0465-5
Anionic nanoparticles increase intestinal permeability and enable the oral delivery of proteins, as shown with the delivery of insulin in healthy, hyperglycaemic, and diabetic mice.Author: Nicholas G. Lamson, Adrian Berger, Katherine C. Fein, Kathryn A. Whitehead
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