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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476983/
Mar 24, 2015 · Research on intranasal delivery of drugs, peptides, and proteins has grown over the past decade as an alternate way to deliver these compounds to the brain. The blood–brain barrier (BBB) limits the ability of most biologicals to enter the central nervous system (CNS).Author: M. Elizabeth Meredith, Therese S. Salameh, William A. Banks
https://www.sciencedirect.com/science/article/pii/S0001868617305171
Alternatively, encapsulation of proteins in delivery systems may alter the rate and extent of their hydrolysis in the GIT, thereby controlling the type and location of bioactive peptides generated within the gastrointestinal tract. At present, there have been few studies on the utilization of colloidal delivery systems for this application.Author: David Julian McClements
https://www.sciencedirect.com/book/9780123849359/peptide-and-protein-delivery
The aim of this chapter is to look at the use of amphiphilic polyelectrolytes and chemically modified chitosan for the gastrointestinal delivery of proteins and peptides, and to discuss how the chemical modifications have impacted on the two important challenges in oral protein/peptide delivery, i.e., protection against intestinal enzymatic ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956587/
Peptides and proteins are readily metabolized in the GI tract, and the hydrophilic nature of most natural peptides restricts movement across the epithelial barrier. Advances in the oral delivery of proteins and peptides have been made by the use of absorption enhancers, enzyme inhibitors and direct structural modification of the therapeutic.Author: Benjamin J Bruno, Geoffrey D Miller, Carol S Lim
https://www.researchgate.net/publication/322468712_Ocular_delivery_of_proteins_and_peptides_Challenges_and_novel_formulation_approaches
Formulation and delivery of proteins and peptides, such as monoclonal antibodies, aptamers, recombinant proteins and peptides to ocular tissues poses significant challenges owing to their large ...
https://www.researchgate.net/publication/328265448_PROTEIN_AND_PEPTIDE_DRUG_DELIVERY_SYSTEM
Protein and Peptide drug delivery system are the Novel drug Delivery System. Proteins and peptides are the most abundant components of biological cells. They exist functioning such as enzymes ...
https://www.ondrugdelivery.com/pulmonary-delivery-antimicrobial-peptides/
The peptides in FORMAMP are new, but peptides for other medical uses have been under investigation for a few decades, as the lung is a suitable route for systemic delivery without first-pass effects. The most studied peptide for pulmonary delivery is insulin, for which rapid systemic delivery is the target.
http://www.pharmtech.com/considering-protein-and-peptide-delivery
Jan 02, 2019 · “Proteins and peptides do not sustain the rigor of the gastrointestinal tract. Chemical degradation in gastric fluids, extensive metabolism in luminal spaces, and first pass metabolism are major concerns with oral delivery of proteins and peptides,” says Nair.
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0154081
Although there have been reports of the delivery of proteins into cultured plant cells, there are currently no methods for the direct delivery of proteins into intact plants, owing to their hierarchical structures. Here, we demonstrate the efficient fusion-peptide-based delivery of proteins …Author: Kiaw Kiaw Ng, Yoko Motoda, Satoru Watanabe, Ahmad Sofiman Othman, Takanori Kigawa, Takanori Kigawa, ...
https://www.umass.edu/cbd/research-themes/proteins-peptides-antibodies
Develop robust capabilities to deliver peptides, proteins, and antibodies to targeted cells and tissues. The team is tackling the challenge of protecting protein-based biologics from protease degradation and deliver them to targeted cells and tissues, and also to specific intracellular compartments. These approaches open up opportunities in “undruggable” targets such as targeting K-Ras and ...
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