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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857543/
If the protein is intended for the antigen delivery or for sustained release and a stable protein that can handle harsh preparation procedure such as exposure to …Author: Dipak S. Pisal, Matthew P. Kosloski, Sathy V. Balu-Iyer
https://pubs.acs.org/doi/10.1021/acs.bioconjchem.9b00096
An ideal delivery method is agnostic—applicable to a large ensemble of proteins or nucleic acids or nanoparticles. Any ensuing conjugate should not impose perturbations that are deleterious to macromolecular structure or function within the cell.Author: Theresa M. Reineke, Ronald T. Raines, Vincent M. Rotello
https://segura.pratt.duke.edu/research/protein-delivery
The delivery of proteins has been widely explored to promote vascularization and tissue repair because of their ability to initiate pro-angiogenic and pro-repair signaling cascades. The Segura Laboratory has explored the delivery of growth factors in both a nanoencapsulated and a tethered approach.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956587/
Peptides and proteins are readily metabolized in the GI tract, and the hydrophilic nature of most natural peptides restricts movement across the epithelial barrier. Advances in the oral delivery of proteins and peptides have been made by the use of absorption enhancers, enzyme inhibitors and direct structural modification of the therapeutic.Author: Benjamin J Bruno, Geoffrey D Miller, Carol S Lim
https://www.sciencedirect.com/science/article/pii/S1319016414000590
A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives. Author links open overlay panel Abdul Muheem a Faiyaz Shakeel b Mohammad Asadullah Jahangir c Mohammed Anwar a Neha Mallick a Gaurav Kumar Jain a Musarrat Husain Warsi a Farhan Jalees Ahmad a. Show more.Author: Abdul Muheem, Faiyaz Shakeel, Mohammad Asadullah Jahangir, Mohammed Anwar, Neha Mallick, Gaurav Kuma...
http://www.iptonline.com/articles/public/IPTNINE106NoPrint.pdf
proteins across the epithelial boundary is paracellular transport. There are tight junctions between each of the cells in the epithelium that prevent water and aqueous soluble compounds from moving past these cells. A number of absorption enhancers are available that will cause these tight junctions to open transiently, allowing water-soluble proteinsFile Size: 228KB
https://www.nature.com/articles/s41551-019-0465-5
The oral delivery of bioactive peptides and proteins is prevented by the intestinal epithelial barrier, in which intercellular tight junction complexes block the uptake of macromolecules. Here we...Author: Nicholas G. Lamson, Adrian Berger, Katherine C. Fein, Kathryn A. Whitehead
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