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https://www.sciencedirect.com/science/article/pii/S0734975011001285
The way forward in the development of plant-made vaccines and therapeutics is to improve bioavailability of the delivered material. This can be achieved through rational and innovative design strategies for better protection and targeting of relevant cellular pathways and immune responsive sites.Author: Assunta Pelosi, Robert Shepherd, Amanda Maree Walmsley
https://www.researchgate.net/publication/51573353_Delivery_of_plant-made_vaccines_and_therapeutics
As commercial approval of the first, purified, plant-based biopharmaceuticals for parenteral delivery to humans approaches, improved strategies for delivery of plant-made vaccines and therapeutics...
https://www.deepdyve.com/lp/elsevier/delivery-of-plant-made-vaccines-and-therapeutics-e0K2ubf9Tv
Mar 01, 2012 · As commercial approval of the first, purified, plant-based biopharmaceuticals for parenteral delivery to humans approaches, improved strategies for delivery of plant-made vaccines and therapeutics are required to ensure their further development and to fulfil the prospect of supplying a global solution for affordable medicines.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787751/
Plant cells are ideal bioreactors for the production and oral delivery of vaccines and biopharmaceuticals, eliminating the need for expensive fermentation, purification, cold storage, transportation and sterile delivery. Plant-made vaccines have been developed for two decades but none has advanced beyond Phase I. However, two plant-made biopharmaceuticals are now …Author: Henry Daniell, Nameirakpam D. Singh, Hugh Mason, Stephen J. Streatfield
https://www.onlinelibrary.wiley.com/doi/10.1111/pbi.12460
In 1992, my research concept had been entirely focused on low‐cost vaccines for oral delivery in the developing world, and for the next several years, I actively promoted the idea of ‘edible vaccines’ (Figure 2). As I have said in recent years that may have attracted attention in the plant biology realm, but it probably has been much more ...Author: Charles Arntzen
https://www.cell.com/trends/biotechnology/pdf/S0167-7799(16)30219-0.pdf
concept of the oral delivery of plant-made biopharmaceuticals using plant biomass has been proven for many candidates [6]. In fact, the adoption of plant-based platforms by the industry hasbecomearealitybecauseseveralproducts,suchasinfluenzavaccines,havecome close to being marketed [7]; a plant-made enzyme for the treatment of Gaucher's disease is
https://www.tandfonline.com/doi/abs/10.1517/17425247.5.6.693
Oct 08, 2008 · Background: M (microfold or membranous) cells are specialised epithelial cells responsible for antigen sampling at the interface of mucosal surfaces and the environment. Their high transcytotic ability make M cells an attractive target for mucosally delivered vaccines and therapeutics. Objective: This brief review discusses the current state of M cell-targeted mucosal delivery systems …Author: Rhonda KuoLee, Wangxue Chen
https://www.who.int/biologicals/vaccines/plant_derived_vaccines/en/
A new and exciting possibility is the production of vaccine antigens in genetically modified plants which can then be extracted and purified by conventional methods. Such vaccines could either be eaten or applied to mucosal surfaces. Plant-derived vaccines have several advantages.
https://www.researchgate.net/publication/38017486_Plant-made_vaccine_antigens_and_Biopharmaceuticals
Plant cells are ideal bioreactors for the production and oral delivery of vaccines and biopharmaceuticals, eliminating the need for expensive fermentation, purification, cold storage, transportation and sterile delivery.
20Med Therapeutics' versatile delivery platform is the result of 15 years of research on bioresponsive polymers and drug delivery. Specifically designed to address all steps of intracellular delivery, 20Med Nanoparticles facilitate efficient transfection of a wide range of oligonucleotide-based therapeutics, ranging from large plasmid DNAs (>12kb) to small antisense oligos.
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