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https://www.researchgate.net/publication/7471419_Delivery_of_plant-derived_vaccines
Plant-based oral vaccines are another delivery system that has been tested in recent years58 59 6061.
https://www.ncbi.nlm.nih.gov/pubmed/16296796
Delivery of plant-derived vaccines. Streatfield SJ(1). Author information: (1)Applied Biotechnology Institute, College Station, TX 77845, USA. [email protected] Many protein subunit vaccine candidates have been expressed in transgenic plants, and in a few cases the recombinant material has entered early phase clinical or target ...Author: Stephen J Streatfield
https://www.who.int/biologicals/vaccines/plant_derived_vaccines/en/
Traditionally vaccines are prepared by using an attenuated version of the pathogen or by preparing and inactivating a disease-causing organism or a suitable part of it, e.g. a toxin, and administering it in quantities sufficient to induce immunity.
https://www.sciencedirect.com/science/article/pii/S0958166900000707
It is well documented that delivery of a plant-derived vaccine to a mucosal tissue induces both a mucosal and a systemic immune response 11, 12, 28, 31, 33••. Intranasal immunization, however, has been the only delivery mechanism to attain this for purified chimeric plant virus expressing a vaccinogen.Author: Amanda M Walmsley, Amanda M Walmsley, Charles J Arntzen
https://www.hindawi.com/journals/jir/2019/8303648/
Intradermal immunization for vaccine delivery is an upcoming strategy showing significant advantages over conventional vaccination routes. In particular, in the last few years, intradermal vaccination has gained momentum as an alternative and more effective vaccine delivery route, both from a scientific and a commercial point of view (Table 3).Author: E. Criscuolo, V. Caputo, V. Caputo, R. A. Diotti, R. A. Diotti, G. A. Sautto, G. A. Kirchenbaum, N. ...
https://www.who.int/immunization/research/meetings_workshops/Dominic_Lam.pdf
The Production and Delivery of Edible Plant- and Lactobacteria-derived Vaccines Dominic Man-Kit Lam Fung Hon Chu Endowed Chair of Humanics Hong Kong Baptist University WHO Meeting at HKBU 24 January 2013 . Acknowledgements of Main Collaborators I. Edible Plants: Prof. Hugh Mason, Prof. Charles Arntzen,
https://www.onlinelibrary.wiley.com/doi/full/10.1111/pbi.12471
The use of transgenic plants to produce subunit vaccine proteins has been developed as an alternative platform for the large‐scale production and delivery of vaccines to induce protective immune responses via the mucosal immune system (Daniell et al., 2009). Vegetable and fruit crops are ideal host systems for oral vaccine production.Author: Hui-Ting Chan, Henry Daniell
https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/bcp.12949
plant derived vaccines and several clinical phase I studies were completed [18]. However, raw potato is unpalatable and cooking has the potential to destroy most protein based vaccine candidates. Therefore, tomato fruits were considered as an alternative delivery vehicle because the fruits are safe and palatable when consumed raw and this platform offersAuthor: Matilde Merlin, Mario Pezzotti, Linda Avesani
https://www.researchgate.net/publication/222535128_Plants_for_delivery_of_edible_vaccines
In general, the cost of PMF-derived products is only 0.1% of mammalian cell culture systems and 2%–10% of microbial systems. An example of an early proof of concept for PMF is the production of plant-derived edible human vaccines, using leafy plants or fruits 30 3132333435.
https://www.hindawi.com/journals/jb/2016/4928637/
Despite using direct gene delivery method, indirect gene delivery methods show more significant efficacy in vaccines production as indirect gene delivery involves the utilization of plant bacteria, particularly the Agrobacterium species and plant viruses, which naturally infect the plant cells and are able to integrate the gene of interest into plant genome .Author: Erna Laere, Anna Pick Kiong Ling, Ying Pei Wong, Rhun Yian Koh, Mohd Azmi Mohd Lila, Sobri Hussein
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