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https://www.sciencedirect.com/science/article/pii/S1461534799001996
However, more recently, spurred on by the advent of novel delivery devices, there is growing interest in the use of the lung for the systemic delivery of challenging molecules, such as peptides and proteins, as well as analgesic agents and even vaccines 19. The lung can provide an excellent means for the rapid delivery of peptide drugs into the blood, providing that the drug can reach deeper regions.Author: Stanley S Davis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59577/
Apr 12, 2001 · The lung as a route for systemic delivery of therapeutic proteins and peptides Remigius Uchenna Agu , 1 Michael Ikechukwu Ugwoke , 2 Michoel Armand , 1 Renaat Kinget , 1 and Norbert Verbeke 1 1 Laboratorium voor Farmacotechnologie en Biofarmacie, KU Leuven, Leuven, BelgiumAuthor: Remigius Uchenna Agu, Michael Ikechukwu Ugwoke, Michoel Armand, Renaat Kinget, Norbert Verbeke
https://www.nature.com/articles/nrd2153
Jan 01, 2007 · The use of the lungs for the systemic delivery of medicines is virtually unexploited, and the ancient human practice of inhaling substances for systemic effect (with the exception of anaesthetic ...Author: John S. Patton, Peter R. Byron
https://www.sciencedirect.com/science/article/pii/B9780123849359100021
A β-lactam-transporting peptide transporter has also been proposed to effect receptor-mediated delivery of certain peptides . In paracellular transport, the molecule moves through junctions between two or more cells, as well as gaps in the membrane formed after the shedding of dead cells [22] .Author: Philip Chi Lip Kwok, Hak-Kim Chan
https://journal.chestnet.org/article/S0012-3692(15)00062-8/fulltext
Proof of principal for therapeutic efficacy of endogenous AMPs in lungs has been delivered by overexpressing LL-37 in the lungs of mice or by direct administration of this peptide to the lungs.Author: Pieter S. Hiemstra, Gimano D. Amatngalim, Anne M. van der Does, Christian Taube
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831480/
Oct 15, 2019 · Peptide-based delivery systems that enable the delivery of therapeutic cargoes into specific cell lines with low toxicity and high therapeutic effect are fundamentally important for peptide cancer vaccines.Author: Lu Zhang, Yanyu Huang, Aaron Raymond Lindstrom, Tzu-Yin Lin, Kit S Lam, Yuanpei Li
https://www.researchgate.net/publication/7399968_Noninvasive_delivery_technologies_Respiratory_delivery_of_vaccines
Aerosol inhalation therapy is an alternative to oral and parenteral approaches for the systemic delivery of drugs to and through the lungs.
https://www.researchgate.net/publication/259200055_Systemic_delivery_of_biotherapeutics_through_the_lung_Opportunities_and_challenges_for_improved_lung_absorption
Inhalation drug delivery directly targeting the lungs through respiratory tract is a rapidly maturing field of research and most recently explored approaches for both local and systemic therapy.Author: Masahiro Sakagami
https://www.wiley.com/en-au/Delivery+Technologies+for+Biopharmaceuticals%3A+Peptides%2C+Proteins%2C+Nucleic+Acids+and+Vaccines-p-9780470723388
Delivery Technologies for Biopharmaceuticals is the first single-volume reference to describe the strategies to overcome the main barriers for successful delivery of all major classes of biopharmaceuticals—peptides, proteins, nucleic acids, and vaccines. With extensive case studies showing how the science has been put into practice, this essential introduction will be of value to researchers and students working in drug delivery…
https://www.nature.com/articles/2402436/
May 02, 2002 · Peptide-Based Cancer Vaccines provides a detailed account of research describing how to identify candidate peptides, what makes up a peptide-based vaccine, what has been learned about delivery …Author: RK Bright
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