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https://www.sciencedirect.com/science/article/pii/S0301008209000124
Peptide and protein (P/P) drugs have been identified as showing great promises for the treatment of various neurodegenerative diseases. A major challenge in this regard, however, is the delivery of P/P drugs over the blood–brain barrier (BBB).Author: Ivona Brasnjevic, Harry W.M. Steinbusch, Christoph Schmitz, Pilar Martinez-Martinez
https://www.deepdyve.com/lp/elsevier/delivery-of-peptide-and-protein-drugs-over-the-blood-brain-barrier-MlgyBAuBfJ
Apr 01, 2009 · Read "Delivery of peptide and protein drugs over the blood–brain barrier, Progress in Neurobiology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
https://www.sciencedirect.com/book/9780123849359/peptide-and-protein-delivery
This chapter highlights the significant advances in brain delivery of peptide and protein drugs made over the past three decades. While many limitations still exist regarding the cerebral delivery of peptide and protein drugs, several strategies show considerable promise for improvement of brain uptake.
https://www.academia.edu/9171413/Delivery_of_peptide_and_protein_drugs_over_the_blood_brain_barrier
Delivery of peptide and protein drugs over the blood–brain barrier
https://www.researchgate.net/publication/24361035_European_NanoBioPharmaceutics_Research_Initiative_Delivery_of_peptide_and_protein_drugs_over_the_blood-brain_barrier
Delivery of peptide and protein drugs over the blood-brain barrier Peptide and protein (P/P) drugs have been identified as showing great promises for the treatment of various neurodegenerative ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1857226/
May 01, 2007 · Treatment of many neuronal degenerative disorders will require delivery of a therapeutic protein to neurons or glial cells across the whole CNS. The presence of the blood–brain barrier hampers the delivery of these proteins from the blood, thus necessitating a new method for delivery.Author: Brian J. Spencer, Inder M. Verma
https://pubs.rsc.org/en/content/articlehtml/2016/cs/c6cs00076b
Blood–brain barrier shuttle peptides: an emerging paradigm for brain delivery. Benjamí Oller-Salvia a, Macarena Sánchez-Navarro a, Ernest Giralt ab and Meritxell Teixidó a a Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain.Author: Benjamí Oller-Salvia, Macarena Sánchez-Navarro, Ernest Giralt, Meritxell Teixidó
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC508366/
Oct 01, 1997 · Vector-mediated delivery of a polyamide ("peptide") nucleic acid analogue through the blood-brain barrier in vivo. Proc Natl Acad Sci U S A. 1995 Jun 6; 92 (12):5592–5596. [PMC free article] Yoshikawa T, Pardridge WM. Biotin delivery to brain with a covalent conjugate of avidin and a monoclonal antibody to the transferrin receptor.Author: William M. Pardridge
https://pubs.acs.org/doi/abs/10.1021/mp400680d
Neurological diseases such as neurodegeneration, pain, psychiatric disorders, stroke, and brain cancers would greatly benefit from the use of highly potent and specific peptide pharmaceuticals. Peptides are especially desirable because of their low inherent toxicity. The presence of the blood brain barrier (BBB), their short duration of action, and their need for parenteral administration ...Author: Aikaterini Lalatsa, Andreas G. Schatzlein, Ijeoma F. Uchegbu
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