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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527479/
The delivery of cytokines as recombinant proteins can result in toxicity and other adverse effects; however the delivery of cytokine genes using EP has been shown to be safe and effective. Interleukin 15 (IL-15) is a cytokine that promotes the innate as well as the adaptive immune response to cancer cells and bacterial pathogens.Author: Bernadette Marrero, Shawna Shirley, Richard Heller
https://stm.sciencemag.org/content/5/201/201ra118.full
Sep 04, 2013 · , Antibody-mediated delivery of interleukin-2 to the stroma of breast cancer strongly enhances the potency of chemotherapy. Clin. Cancer Res. 14 , 6515 – 6524 ( 2008 ).Author: Katrin L. Gutbrodt, Christoph Schliemann, Leonardo Giovannoni, Katharina Frey, Thomas Pabst, Wolfram...
https://www.ncbi.nlm.nih.gov/pubmed/26962109
Aug 01, 2016 · Delivery of interleukin-10 via injectable hydrogels improves renal outcomes and reduces systemic inflammation following ischemic acute kidney injury in mice. Soranno DE(1), Rodell CB(2), Altmann C(3), Duplantis J(4), Andres-Hernando A(3), Burdick JA(2), Faubel S(3).Author: Danielle E. Soranno, Christopher B. Rodell, Christopher Altmann, Jane Duplantis, Ana Andres-Hernando...
https://clincancerres.aacrjournals.org/content/18/15/4092
Aug 01, 2012 · Purpose: Interleukin-12 (IL12) is a potent proinflammatory cytokine with antitumor activity. Its heterodimeric nature makes it compatible with a large variety of different immunocytokine formats. Here we report the design, production, and characterization of a novel immunocytokine, based on the fusion of the F8 antibody (specific to the alternatively spliced EDA domain of fibronectin, a …Author: Nadine Pasche, Sarah Wulhfard, Francesca Pretto, Elisa Carugati, Dario Neri
https://academic.oup.com/humrep/article/26/9/2344/721427
Jun 24, 2011 · The antibody-mediated targeted delivery of interleukin-10 inhibits endometriosis in a syngeneic mouse model Kathrin Schwager. 1. Philochem AG, c/o ETH Zurich, Institute of Pharmaceutical Sciences, Wolfgang-Pauli-Str. 10 HCI E520, CH-8093 Zurich, Switzerland. Search for …Author: Kathrin Schwager, Frank Bootz, Patrick Imesch, Manuela Kaspar, Eveline Trachsel, Dario Neri
https://www.semanticscholar.org/paper/Sustained-Delivery-of-Interleukin-2-from-a-407-Gel-Johnston-Punjabi/92d299c63cbeb98715e8c486224272bdf7eb62c2
Parenteral delivery of recombinant biologic response modifiers (BRMs) remains a challenge because of the brief intravascular half-life of most recombinant proteins and their associated rapid clearance from the circulation. Recombinant derived interleukin-2 (rIL-2) was formulated with Pluronic F-127, N.F. (poloxamer 407, N.F.) and the biological activity determined vs time at 4, 22, and 37°C ...
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