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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267434/
Aug 10, 2007 · For example CCCP is a compound used to disrupt the electrochemical potential of the organelle and it simply diffuses across the membrane. The concept of hydrophobic molecules as carriers of drugs into mitochondria was turned into reality when triphenyl phosphonium ion was shown to cross into the matrix space [61,62]. Functional groups could be ...Author: Abhijit Mukhopadhyay, Henry Weiner
https://www.sciencedirect.com/science/article/pii/S0168365915301863
Mitochondria are organelles that have pivotal functions in producing the energy necessary for life and executing the cell death pathway. Targeting drugs and macromolecules to the mitochondria may provide an effective means of inducing cell death for cancer therapy, and has been actively pursued in …Author: Phong Lu, Benjamin J. Bruno, Malena Rabenau, Carol S. Lim
https://www.sciencedirect.com/science/article/pii/S0169409X99000691
Drug delivery to mitochondria: the key to mitochondrial medicine. Author links open overlay panel Michael P Murphy a Robin A.J Smith b. ... Here we outline how mitochondria contribute to human diseases to illustrate why delivery of drugs or bioactive molecules to mitochondria may be …Author: Michael P Murphy, Robin A.J Smith
https://www.ncbi.nlm.nih.gov/pubmed/17659805
Aug 10, 2007 · Delivery of drugs and macromolecules to mitochondria. Mukhopadhyay A(1), Weiner H. Author information: (1)Department of Biochemistry, Purdue University, 175 S. University Street, West Lafayette, Indiana 47907-2063, USA. [email protected] Mitochondria is where the bulk of the cell's ATP is produced.Author: Abhijit Mukhopadhyay, Henry Weiner
https://pubs.acs.org/doi/10.1021/jacs.0c00188
Mitochondria play a key role in oncogenesis and constitute one of the most important targets for cancer treatments. Although the most effective way to deliver drugs to mitochondria is by covalently linking them to a lipophilic cation, the in vivo delivery of free drugs still constitutes a critical bottleneck. Herein, we report the design of a mitochondria-targeted metal–organic framework ...Author: Salame Haddad, Isabel Abanades Lazaro, Marcus Fantham, Ajay Mishra, Joaquin Silvestre-Albero, Johann...
https://www.researchgate.net/publication/283049925_Delivery_of_drugs_and_macromolecules_to_the_mitochondria_for_cancer_therapy
Mitochondria are organelles that have pivotal functions in producing energy necessary for life and executing the cell death pathway. Targeting drugs and macromolecules to the mitochondria may ...
https://www.researchgate.net/publication/6178823_Delivery_of_Drugs_and_Macromolecules_to_Mitochondria
Delivery of Drugs and Macromolecules to Mitochondria Article · Literature Review in Advanced Drug Delivery Reviews 59(8):729-38 · September 2007 with 42 Reads How we measure 'reads'
https://www.intechopen.com/books/toxicology-studies-cells-drugs-and-environment/mitochondrial-targeting-for-drug-development
Owing to the unique structure and function of mitochondria, several clinically used drugs can improve or damage their bioenergetics. ... or RNAi molecules by the delivery of viral vectors (14–16) to silence SOD1 mutant gene expression. In gene ... (July 8th 2015). Mitochondrial Targeting for Drug Development, Toxicology Studies - Cells, Drugs ...Author: Jalal Pourahmad, Ahmad Salimi, Enayatollah Seydi
https://pubs.acs.org/doi/abs/10.1021/cb400095v
These results indicate that targeting drugs to the mitochondria provides a means to limit drug efflux and provide evidence that a mitochondrially targeted DNA topoisomerase poison is active within the organelle. ... Mitochondria as an Emerging Target for the Delivery of Small Therapeutic Molecules. 2016,,, 259-289. DOI: 10.1201/9781315370118-12.Author: Graham R. Chamberlain, David V. Tulumello, Shana O. Kelley
https://link.springer.com/chapter/10.1007%2F978-3-319-11355-5_7
Nov 05, 2014 · Targeting of biologically active molecules to mitochondria in living cells open up ways for modifying mitochondrial functions, which may come with selective protection, repair or eradication of cells. Furthermore, nanoscience offers unique tools and materials to target therapeutic agents to …Author: Udita Agrawal, Rajeev Sharma, Suresh P. Vyas
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