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https://www.sciencedirect.com/science/article/pii/S0142961218308202
Delivery of miR-212 by chimeric peptide-condensed supramolecular nanoparticles enhances the sensitivity of pancreatic ductal adenocarcinoma to doxorubicinAuthor: Wei Chen, Yue Zhou, Xiao Zhi, Tao Ma, Hao Liu, Brayant Wei Chen, Xiaoxiao Zheng, Shangzhi Xie, Bin Z...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973361/
Jul 28, 2016 · The biological effect of the exosome-mediated delivery of miR-9 was investigated performing migration and invasion assays on recipient NFs. The internalization of this miRNA resulted in stronger cell motility (Figure 3d).Author: S Baroni, S Romero-Cordoba, I Plantamura, M Dugo, E D’Ippolito, Alessandra Cataldo, G Cosentino, V A...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665167/
Delivery of miR-34a by chitosan/PLGA nanoplexes for the anticancer treatment of multiple myelomaAuthor: Donato Cosco, Felisa Cilurzo, Jessica Maiuolo, Cinzia Federico, Maria Teresa Di Martino, Maria Chiar...
https://www.sciencedirect.com/science/article/abs/pii/S2162253116301895
MicroRNAs (miRs) regulate physiological processes, such as resistance of GBM cells to temozolomide (TMZ). Although miRs are attractive targets for cancer therapeutics, the effectiveness of this approach requires targeted delivery. Mesenchymal stem cells (MSCs) …Author: Jessian L Munoz, Sarah A Bliss, Steven J Greco, Shakti H Ramkissoon, Shakti H Ramkissoon, Keith L Li...
https://www.sciencedirect.com/science/article/pii/S2162253117301609
Targeted miRNAs delivery for amplification of neurogenesis is promising in promoting the prognosis after ischemia. Here, we showed that modified exosomes, with rabies virus glycoprotein (RVG) fused to exosomal protein lysosome-associated membrane glycoprotein 2b (Lamp2b), could efficiently deliver miR-124 to the infarct site.Author: Jialei Yang, Jialei Yang, Xiufen Zhang, Xiangjie Chen, Lei Wang, Guodong Yang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009470/
Systemic delivery of miR-34a containing vehicles displayed unchanged levels of cytokines and liver enzymes in the blood circulation, indicating the neutral lipid-based delivery system is a safe and non-immunogenic formulation. Furthermore, formulated miR-34a inhibited tumor growth significantly in xenograft mouse models of NSCLC.Author: Yunching Chen, Dong Yu Gao, Leaf Huang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460833/
The researchers found evidence that miR-196a was up-regulated in the diseased mice as a protective mechanism against the progression of the disease and decided that they would attempt to treat the disease by aiding the natural up-regulation of miR-196a by bolstering the amount of this miRNA with a delivery of exogenous miR-196a.Author: Jun Xie, Daniel Robert Burt, Daniel Robert Burt, Guangping Gao, Guangping Gao
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