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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · The purpose of this report was to provide a broad and comprehensive overview on the multiple barriers, the diverse carrier systems, and the current status of the clinical development of siRNA therapeutics. This review contains four parts. Part 1 describes the mechanisms of RNAi.Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727154/
Within the past two decades we have become increasingly aware of the roles that RNAs play in regulation of gene expression. The RNA world was given a booster shot with the discovery of RNA interference (RNAi), a compendium of mechanisms involving small RNAs (less than 30 bases long) that regulate the expression of genes in a variety of eukaryotic organisms.Author: Daniel H. Kim, John J. Rossi
https://www.sciencedirect.com/science/article/pii/S1818087614000646
The currently developed siRNA delivery systems for cancer therapy can be divided into four categories: chemical modifications, lipid-based nanovectors, polymer-mediated delivery systems, conjugate delivery systems, and others (exosomes, RNAi-microsponges, oligonucleotide nanoparticles). 4.1. Chemical modifications of anti-cancer siRNAAuthor: Cong-fei Xu, Jun Wang
https://www.nature.com/articles/d41586-019-03071-9
Oct 16, 2019 · Delivery has been such a significant challenge that those working in the area of RNAi therapeutics might be forgiven for admitting defeat. And there’s …Author: Bianca Nogrady
https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-017-0683-y
Jul 28, 2017 · Although RNAi molecules are effective in silencing oncogenes, it is critical to identify the RNAi regulatory network rather than just a few isolated targets. Thus, more studies on the delivery of RNAi molecules by nanoparticles in cancer therapy are needed to establish a …Author: Yong Xin, Min Huang, Wen Wen Guo, Qian Huang, Long zhen Zhang, Guan Jiang
https://www.cell.com/molecular-therapy-family/molecular-therapy/pdf/S1525-0016(16)31081-4.pdf
ing this potential is the safe and efficacious delivery of short-interfering RNAs (siRNAs), the molecules that mediate RNAi, to specific cell types and tissues. In recent years, significant progress has been made to overcome some of the obstacles associated with in vivo delivery of siRNA, and lipid nanoparticles (LNPs) represent
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)31081-4
Accordingly, both endogenous and exogenous targeting mechanisms have been delineated for delivery of RNAi therapeutics, and represent novel strategies for …Author: Akin Akinc, William Querbes, Soma De, June Qin, Maria Frank-Kamenetsky, K Narayanannair Jayaprakash,...
https://molecular-cancer.biomedcentral.com/track/pdf/10.1186/s12943-017-0683-y?site=molecular-cancer.biomedcentral.com
REVIEW Open Access Nano-based delivery of RNAi in cancer therapy Yong Xin1, Min Huang1, Wen Wen Guo1, Qian Huang1, Long zhen Zhang1 and Guan Jiang2* Abstract Background: RNA interference (RNAi), a newly developed method in which RNA molecules inhibit gene
https://www.nature.com/articles/3302694
Dec 08, 2005 · RNA interference (RNAi) is a powerful gene-silencing process that holds great promise in the field of cancer therapy. The discovery of RNAi has …Author: S. I. Pai, Y. Y. Lin, B. Macaes, A. Meneshian, Chien-Fu Hung, Tzyy Choou Wu
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