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https://avantilipids.com/product/640009
siRNA Delivery Kit Lipids. Please Confirm Your Location. Effective March 1, 2018, Merck KGaA, Darmstadt, Germany* is the exclusive Distributor of Avanti Polar Lipids, Inc. Research Products for all countries except the United States.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006685/
Although the cationic lipid-based delivery systems have demonstrated the potential of siRNA as future human medicines, they still need more development effort . Lipid-based liposomes used to deliver siRNA do not have optimal encapsulation efficiency; that is, many siRNA molecules stay freely in solutions.Author: Shubiao Zhang, Shubiao Zhang, Defu Zhi, Leaf Huang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849731/
Apr 15, 2010 · The design of appropriate gene delivery systems is essential for the successful application of gene therapy to clinical medicine. Cationic lipid-mediated delivery is a viable alternative to viral vector-mediated gene delivery in applications where transient gene expression is desirable.Author: S. Zou, K. Scarfo, M.H. Nantz, J.G. Hecker
https://www.nature.com/articles/s41467-019-13727-9
Dec 19, 2019 · Oral microbiota delivery is an approach to treat and prevent disease but suffers from low retention and bioavailability. Here the authors report on a lipid coating to protect against environmental ...Author: Zhenping Cao, Xinyue Wang, Yan Pang, Shanshan Cheng, Jinyao Liu
https://altogen.com/product/lipid-in-vivo-transfection-reagent/
Altogen Biosystems provides in vivo transfection reagents, over 100 pre-optimized in vitro transfection kits for cell lines and primary cells, and electroporation delivery products. Transfection reagents are highly efficient for DNA and siRNA transfection in vivo and in vitro. Altogen CRO offers in vivo RNAi services, tumor xenograft models, toxicology testing, stable cell line generation, and ...
https://www.sciencedirect.com/science/article/pii/S0009308419300465
At present, various lipid systems have been explored for gene transfection or OND delivery. In the following, some of them will be discussed in more detail, supported by representative examples of their potential therapeutic applications with special focus on miRNA delivery.Author: Marcel Scheideler, Ivan Vidakovic, Ruth Prassl
https://www.sciencedirect.com/science/article/pii/S2162253120300536
The efficient delivery of antisense oligonucleotides (ASOs) to the targeted cells and organs remains a challenge, in particular, in vivo.Here, we investigated the ability of a library of biodegradable lipid nanoparticles (LNPs) in delivering ASO to both cultured human cells and animal models.Author: Liu Yang, Feihe Ma, Fang Liu, Jinjin Chen, Xuewei Zhao, Qiaobing Xu
https://pubs.acs.org/doi/10.1021/mp100390w
Biodegradable core−shell structured nanoparticles with a poly(β-amino ester) (PBAE) core enveloped by a phospholipid bilayer shell were developed for in vivo mRNA delivery with a view toward delivery of mRNA-based vaccines. The pH-responsive PBAE component was chosen to promote endosome disruption, while the lipid surface layer was selected to minimize toxicity of the polycation core ...Author: Xingfang Su, Jennifer Fricke, Daniel G. Kavanagh, Darrell J. Irvine
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(18)30118-7
Sabnis et al. describe a novel amino lipid series for lipid nanoparticle-mediated delivery of mRNA. Enhanced delivery efficiency attributed to increased endosomal escape is demonstrated. An improved tolerability profile enables the first example of safe repeat dosing of mRNA containing lipid nanoparticles in non-human primate at therapeutically relevant levels.Author: Staci Sabnis, E. Sathyajith Kumarasinghe, Timothy Salerno, Cosmin Mihai, Tatiana Ketova, Joseph J. S...
http://www.jbc.org/content/276/37/35103.long
Sep 14, 2001 · The lipid-mediated delivery system also has some limitations; it works well for some but not all proteins as illustrated with cytochrome c, a basic protein. One of the fundamental differences between developing nucleic acid and protein delivery systems …Author: Olivier Zelphati
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