Delivery Drug Modification Peptide

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Protein and Peptide Drug Delivery: Oral Approaches

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792531/
    Designing and formulating a protein and peptide drug for delivery though GI tract requires a multitude of strategies. The dosage form must initially stabilize the drug making it easy to take orally 4. It must then protect the drug from the extreme acidity and action of pepsin in the stomach.

Optimizing the Delivery of Peptide-Based Therapeutics

    https://www.genengnews.com/magazine/297/optimizing-the-delivery-of-peptide-based-therapeutics/
    The Medici Drug Delivery System is a matchstick-sized osmotic minipump that is placed just under the dermal layer of the skin to deliver a continuous and consistent flow of medication. This system, which was developed by Intarcia Therapeutics, allows for proteins, peptides, antibody fragments,...

Basics and recent advances in peptide and protein drug ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956587/
    Direct peptide modifications, liposomes, and NPs are used to increase stability, while the addition of antibodies and CPPs are used for targeting and to supplement cellular delivery. Endosomal escape, which threatens to inactivate the therapeutic peptide at …Author: Benjamin J Bruno, Geoffrey D Miller, Carol S Lim

Protein/Peptide Drug Delivery Systems: Practical ...

    https://www.sciencedirect.com/science/article/pii/B9780128179093000169
    Among the peptide-membrane transporter proteins that have been identified in mammals is the PepT1 membrane transporter protein, which is of high importance for the oral delivery of drug molecules. This peptide transporter has been shown to be involved in the transport of peptidomimetic drugs such as the antiviral drug acyclovir, which bears a structural resemblance to dipeptides.Author: Pran Kishore Deb, Omar Al-Attraqchi, Balakumar Chandrasekaran, Anant Paradkar, Rakesh K. Tekade

(PDF) PROTEIN AND PEPTIDE DRUG DELIVERY SYSTEM

    https://www.researchgate.net/publication/328265448_PROTEIN_AND_PEPTIDE_DRUG_DELIVERY_SYSTEM
    Protein and Peptide drug delivery system are the Novel drug Delivery System. Proteins and peptides are the most abundant components of biological cells. They exist functioning such as enzymes, hormones, structural element and immunoglobulin. The twenty different naturally occurring amino acids …

ORAL PEPTIDE DELIVERY: TECHNOLOGY LANDSCAPE & CURRENT ...

    https://www.ondrugdelivery.com/review-oral-peptide-delivery/
    Injectable sustained-release formulations of peptides demonstrated the power of drug delivery technologies to enhance patient adherence and convenience, and increase safety and efficacy. However, the pain and invasiveness of injections, as well as disposal issues associated with used needles and relatively complicated administration protocols mean that alternative routes of delivery are highly desirable for peptides.

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