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https://www.sciencedirect.com/science/article/pii/S0022354915506242
Research Articles Microfabricated Microneedles: A Novel Approach to Transdermal Drug Delivery Sebastien Henry, †‡ Devin V. McAllister, †§ Mark G. Allen, * ∥ [email protected] Mark R. Prausnitz, * ‡ § [email protected] Institute for Bioengineering and Bioscience, School of Chemical Engineering, School of Electrical and Computer Engineering, and School of ...Author: Sebastien Henry, Devin V. McAllister, Mark G. Allen, Mark R. Prausnitz
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534972/
May 01, 2012 · For example, the microfabricated oral drug delivery system can be manufactured to have increased contact with the intestinal wall, while minimizing shear disturbances and allowing for unidirectional drug release from a protected reservoir to enhance their retention in the body.Author: Shilpa Sant, Shilpa Sant, Shilpa Sant, Sarah L. Tao, Omar Z. Fisher, Qiaobing Xu, Nicholas A. Peppas...
https://www.pnas.org/content/pnas/100/24/13755.full.pdf
drug delivery for over a century, but advances in biotech-nology make their limitations increasingly apparent. As devices that transport molecules of nanometer dimensions, the millime-ter and larger length scales of conventional needles are often unnecessary, and they cause pain and limit targeted delivery. WeAuthor: Devin V. McAllister, Ping M. Wang, Shawn P. Davis, Jung-Hwan Park, Paul J. Canatella, Mark G. Allen,...
https://www.researchgate.net/publication/316545164_Microfabricated_oral_drug_delivery_systems
Fig. 3: Working of a microfabricated drug delivery . system. INDIAN DRUGS 52 (11) NOVEMBER 2015 9 . drug release and hence enhances the oral delivery of . pharmaceuticals 1,10.
https://www.sciencedirect.com/science/article/pii/S0378517305006460
These microfabricated drug delivery devices can enable efficient drug delivery that was unattainable with conventional drug delivery techniques, resulting in the enhancement of the therapeutic activity of a drug. The future of drug delivery is assured to be significantly influenced by microfabrication technologies.Author: J. Zachary Hilt, Nicholas A. Peppas
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850550/
The polymer-based, multi-functional neural interface is capable of electrical stimulation and recording, targeted drug delivery, and electrochemical sensing. A variety of different electrode and fluidic channel arrangements are possible with this fabrication process.Author: Angela Tooker, Teresa E. Madsen, Allison Yorita, Andrea Crowell, Kedar G. Shah, Sarah Felix, Helen S...
https://www.ee.ucla.edu/events/microfabricated-microdevices-for-drug-delivery-vaccination-and-other-biomedical-applications/
Novel formulations will be emphasized that control drug transport during and after injection. Overall, this presentation will use these two case studies to demonstrate the ability of microfabricated microdevices to be translated from device design and fabrication through human clinical trials.
http://drugdelivery.chbe.gatech.edu/Papers/Thesis/Henry_Sebastien_thesis.pdf
would consist of hollow microneedles or plain microspikes mounted onto a drug reservoir. The development of such a device originates from the fact that transdermal drug delivery is a way of administering drugs that overcomes, to some extent, the limitations of oral delivery, the most common method of drug administration.Author: Sʹebastien Henry
http://drugdelivery.chbe.gatech.edu/Papers/1998/Henry%20J%20Pharm%20Sci%201998.pdf
Microfabricated Microneedles: A Novel Approach to Transdermal Drug Delivery SEBASTIEN HENRY,†,‡ DEVIN V. MCALLISTER,‡,§ MARK G. ALLEN,*, AND MARK R. PRAUSNITZ*,‡,§ Contribution from Institute for Bioengineering and Bioscience, School of Chemical Engineering, School of Electrical and Computer Engineering, and School of Mechanical Engineering, Georgia Institute of …
https://pubs.rsc.org/en/content/articlelanding/2018/lc/c8lc00408k
Microfabricated devices show promise to overcome some of these hindrances and thereby improve the bioavailability of drugs after oral administration. There is an increasing focus on microfabricated oral drug delivery systems, and so far there have been three main groups of designs: patch-like structures, microcontainers and microwells.Author: Line Hagner Nielsen, Stephan Sylvest Keller, Anja Boisen
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