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https://www.sciencedirect.com/science/article/pii/S0169409X98000544
4. Toxicity of cyclodextrins in nasal drug delivery 4.1. Local effects. The safety of cyclodextrins as nasal absorption enhancers is determined by two factors: first by their direct effects on the nasal epithelium, i.e. local toxicity, and second by their systemic effects after …Author: F.W.H.M Merkus, J.C Verhoef, E Marttin, S.G Romeijn, P.H.M van der Kuy, W.A.J.J Hermens, N.G.M Schip...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147107/
Nasal drug delivery system. The use of nasal mucosa for transporting drugs is a novel approach for the systemic delivery of high potency drugs with a low oral bioavailability, due to extensive gastrointestinal breakdown and high hepatic first-pass effect.
https://www.researchgate.net/publication/7471382_Cyclodextrins_in_drug_delivery_Review
Cyclodextrins in drug delivery (Review) Article · Literature Review (PDF Available) in Expert Opinion on Drug Delivery 2(2):335-51 · April 2005 with 3,380 Reads How we measure 'reads'
https://www.researchgate.net/publication/12479996_Cyclodextrin_in_nasal_drug_delivery
Cyclodextrin in nasal drug delivery Article (PDF Available) in Advanced drug delivery reviews 36(1):41-57 · April 1999 with 564 Reads How we measure 'reads'
https://cyclodextrinnews.com/2020/02/14/nasal-delivery-with-beta-cyclodextrin-is-approved-a-short-story-of-baqsimi/
Cyclodextrins have not been popular excipients for nasal or pulmonary drug delivery so far. This can change soon, with the appearance of a new product from Lilly, called Baqsimi. Baqsimi contains beta cyclodextrin (BCD) as an inactive ingredient. FDA approved the product last summer, and EMA approved the product in the end of 2019.
https://www.sciencedirect.com/science/article/abs/pii/S0169409X98000544
Nasal drug delivery is an attractive approach for the systemic delivery of high potency drugs with a low oral bioavailability due to extensive gastrointestinal breakdown and high hepatic first-pass effect. For lipophilic drugs nasal delivery is possible if they can be dissolved in the dosage form.Author: F.W.H.M Merkus, J.C Verhoef, E Marttin, S.G Romeijn, P.H.M van der Kuy, W.A.J.J Hermens, N.G.M Schip...
https://link.springer.com/chapter/10.1007/978-94-011-5448-2_85
Abstract. Cyclodextrins (CDs) are used as excipients in nasal drug formulations because they act as solubilisers and/or absorption enhancers. With several CDs very efficient nasal drug absorption has been reported, but large interspecies differences have been found.Author: E. Marttin, J. C. Verhoef, S. G. Romeijn, F. W. H. M. Merkus
https://www.ncbi.nlm.nih.gov/pubmed/9769018
Cyclodextrins are used in nasal drug delivery as absorption enhancing compounds to increase the intranasal bioavailability of peptide and protein drugs. The most effective cyclodextrins in animal experiments are the methylated derivatives, dimethyl-beta-cyclodextrin and randomly methylated beta-cyclodextrin, which are active at low ...Author: E. Marttin, J. C. Verhoef, F. W.H.M. Merkus
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